A Case Approach to Perioperative Drug-Drug Interactions

A Case Approach to Perioperative Drug-Drug Interactions

By: Erica D. Wittwer (editor), Toby N. Weingarten (editor), Juraj Sprung (editor), Dull Dull (editor), Michael P. Hutchens (editor), David G. Metro (editor), Wayne T. Nicholson (editor), Kirk Lalwani (editor), Catherine Marcucci (editor), Kirsch Kirsch (editor)Paperback

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Description

The occurrence of deleterious or even fatal drug-drug interactions (DDIs) in the perioperative period is no longer a theoretical concern but a harrowing reality. A Case Approach to Perioperative Drug-Drug Interactions addresses the complex realm of pharmacokinetic drug interactions in an easy-to-read volume that functions as both a comprehensive clinical reference and a casebook. The book presents a summary of the core concepts of drug interactions; an organized, annotated presentation of the drug interactions most relevant to the perioperative clinician; and approximately 200 case scenarios that highlight specific drug interactions. This book fills a real void in the clinical literature and is invaluable to anesthesiologists and surgeons, as well as trainees in both specialties; intensive care staff, including physicians, physician's assistants, and nurses; and nurse practitioners who staff preoperative evaluation clinics.

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About Author

Catherine Marcucci, MD Anesthesia Services Department Philadelphia Veterans Affairs Medical Center Philadelphia, PA, USA Michael P. Hutchens, MD, MA Department of Anesthesiology & Perioperative Medicine Oregon Health & Science University Portland, OR, USA Erica D. Wittwer, MD, PhD Department of Anesthesiology Mayo Clinic Rochester, MN, USA Toby N. Weingarten, MD Department of Anesthesiology Mayo Clinic Rochester, MN, USA Juraj Sprung, MD, PhD Department of Anesthesiology Mayo Clinic Rochester, MN, USA Wayne T. Nicholson, MD, PharmD, MSc Department of Anesthesiology Mayo Clinic Rochester, MN, USA Kirk Lalwani, MD, FRCA, MCR Department of Anesthesiology & Perioperative Medicine Oregon Health & Science University Portland, OR, USA David G. Metro, MD Department of Anesthesiology University of Pittsburgh School of Medicine Pittsburgh, PA, USA Randal O. Dull, MD, PhD Department of Anesthesiology University of Illinois at Chicago Chicago, IL, USA Christopher E. Swide, MD Department of Anesthesiology & Perioperative Medicine Oregon Health & Science University Portland, OR, USA F. Jacob Seagull, PhD Department of Medical Education University of Michigan Medical School Ann Arbor, MI, USA Jeffrey R. Kirsch, MD Department of Anesthesiology & Perioperative Medicine Oregon Health & Science University Portland, OR, USA Neil B. Sandson, MD Department of Psychiatry University of Maryland Medical System Department of Psychiatry VA Maryland Health Care System Baltimore, MD, USA

Contents

Part I. Introduction to Drug-Drug Interactions 1. Let's Start at the Very Beginning: Overcoming Fear and Gaining Mastery of Drug-Drug Interactions F. Jacob Seagull, PhD, Catherine Marcucci, MD 2. Pharmacodynamic Interactions: Core Concepts Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 3. Pharmacokinetic Interactions: Core Concepts Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 4. A Brief Treatise On The Area Under The Curve Michael J. Sikora, MD, Barbara Jericho, MD Part II. Introduction to Drug-Drug Interactions: Brief Review of CYP450 Enzymes, UGTs, and Transporters 5. CYP2D6: Where It All Began John C. Sanders, MBBS, FRCA, Rachel Koll, MD, Randal O. Dull, MD, PhD 6. CYP2E1: The Anesthesia Enzyme Benjamin S. Gmelch, MD, Randal O. Dull, MD, PhD 7. CYP3A4: The Workhorse Jennifer DeCou, MD, Nathaniel Birgenheier, MD, Randal O. Dull, MD, PhD 8. CYP1A2: The Switch-hitter Danielle Roussel, MD, Emily Hagn, MD, Randal O. Dull, MD, PhD 9. CYP2B: 2B or Not 2B? Dustin Coyle, MD, Randal O. Dull, MD, PhD 10. CYP2C9: The Support Crew I Byron Douglas Fergerson, MD, Crystal B. Wallentine, MD, Randal O. Dull, MD, PhD 11. CYP2C19: The Support Crew II Barbara Jericho, MD, Alfredo Aguiar, MD, Randal O. Dull, MD, PhD 12. UGTs: Conjugating Cousins Neil B. Sandson, MD 13. The Cytochrome P450 System In Disease States-A Brief Review Catherine Marcucci, MD PART III. Drug-Drug Interactions: Paradigms and Core Concepts 14. P-glycoprotein and OATP Transporters Dustin Coyle MD, Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD 15. The "Fatal" Forty Neil B. Sandson MD, Michael Hutchens MD, F. Jacob Seagull, PhD, Catherine Marcucci, MD 16. The Six Patterns of Pharmacokinetic Drug-Drug Interactions Neil B. Sandson, MD, Catherine Marcucci, MD 17. The Problem with the Drug-Drug Interaction Software: A Procrustean Dilemma Neil B. Sandson, MD, F. Jacob Seagull, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD 18. Pharmacogenomics Chad D. Moore, PhD, William Hartman, MD, PhD, Michael Hutchens, MD, Randal O. Dull, MD, PhD 19. The Pharmacoepidemiology of Drug Interactions: Why and How They Are Important Joseph A. Lovely, PharmD, BCPS, Stephen Esper, MD, MBA, Michael Hutchens, MD, Wayne T. Nicholson, MD, PharmD, MSc, Catherine Marcucci, MD 20. The Lawyers Can Read, Too: Case Presentations from the Courtroom Jessica Voge, MD, David K. Miller, JD Part IV. Drug-Drug Interactions Involving Inhalational Anesthetic Agents 21. Introduction Catherine Marcucci, MD 22. That Sums It Up Volatile anesthetics, additive MACs James A. Jernigan, MD, James W. Ibinson, MD, PhD 23. 1+1+1+1=? Variable effects of combined substances Anthony T. Silipo, DO, Raymond M. Planinsic, MD, Erica D. Wittwer, MD, PhD, Juraj Sprung MD,PhD, Wayne T. Nicholson, MD, PharmD, MSc 24. A Delayed Surgeon Is A "Dismayed" Surgeon? Nitrous oxide, dexmedetomidine, somatosensory evoked potentials Jonathan Anson, MD 25. Relax, It's Only Gentamicin Volatile anesthetics, aminoglycoside antibiotics, neuromuscular junction Brian Gierl, MD, Ferenc E. Gyulai, MD 26. Jaundice After Surgery Halothane hepatitis, CYP2E1 Jonathon E. Kivela, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 27. Everybody Clear? Halothane, epinephrine arrhythmia Nikhli Patel, MD, Barbara Jericho MD, Randal O. Dull, MD, PhD 28. The Hemodynamic Hole general anesthetics, ACE-I, ARBs Arun L. Jayaraman, MD, PhD, Theresa A. Gelzinis, MD 29. Alpha-2 To The Rescue But Beware Bradycardia volatile anesthetics, alpha-2 agents Phillip Adams, DO, Nashaant N. Rizk, MD 30. Hot Stuff! triggering drugs, ryanodine receptor, malignant hyperthermia Cornelius B. Groenewald, MD, ChB, Juraj Sprung, MD, PhD Part V. Drug-Drug Interactions Involving Intravenous Anesthetic Agents 31. Introduction Catherine Marcucci, MD 32. How to Successfully Occlude an Intravenous Line thiopental, succinylcholine, line precipitation Helga Komen, MD, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD 33. A Curious Cause of Seizures ketamine, theophylline Charles Galaviz, MD, Randal O. Dull, MD, PhD 34. Magnesium Mama And The Mad Dad magnesium sulfate, propofol, remifentanil, vecuronium Ana Maria Manrique MD, Catherine Marcucci, MD, Kathirvel Subramaniam, MD 35. Dexy's Midnight Spinal dexmedetomidine, bupivaine spinal, multiple mechanisms, CYP3A4, CYP2D6 Michael Hutchens, MD, Edward A. Kahl, MD, Matthias J. Merkel, MD, PhD Part VI. Drug-Drug Interactions Involving Local Anesthetics 36. Introduction Catherine Marcucci, MD 37. Comfortably Numb local anesthetics Joseph J. Yurigan, DO, Todd M. Oravitz, MD 38. Naturally Occurring And Nasty cocaine, propranolol Lauren Partyka, MD, Li Meng, MD, MPH 39. LOL-LOL: Little Old Lady-Lots of Lido lidocaine, bupivacaine Kitling M. Lum, RN, BSN, CCRN-CSC, Kelly N. Stafford, BSN, CCRN, CSC 40. The Spinal Countdown general anesthesia after spinal anesthesia Audra M. Webber, MD, Franklyn P. Cladis, MD, FAAP 41. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun I Fatal Forty DDI: ropivacaine, fluoxetine, CYP1A2, CYP3A4 L. Michele Noles, MD 42. Are Drug-Drug Interactions The Smoking Guns of Local Anesthetic Toxicity? Smoking Gun II Fatal Forty DDI: bupivacaine, methocarbamol L. Michele Noles, MD 43. A Perfect Storm? Fatal Forty DDI: omeprazole, nicardipine, diltiazem, bupivacaine, CYP3A4, CYP2C19, CYP2D6 J. Andrew Dziewit, MD, Nabil M. Elkassabany, MD 44. Shake Rattle and Roll Fatal Forty DDI: lidocaine, cimetidine, CYP3A4 Hans P. Sviggum, MD, Juraj Sprung, MD, PhD 45. Hello, We Have A Patient With Acute Delirium and We Need An Urgent Psych Consult lidocaine, metoprolol Katarina Bojanic, MD, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD 46. Fatal Pain Relief local anesthetics, intrathecal morphine Matthew M. Kumar, MD, Richard Levi Boortz-Marx, MD, MS 47. Lipid Lifesaver local anesthetic, lipid emulsion Adrian Pichurko, MD, Guy Weinberg, MD Part VII. Drug-Drug Interactions Involving Opioids 48. Introduction Toby N. Weingarten, MD 49. No 'Subs'titute for Sobriety buprenorphine, mu agonist opioids James Hilliard, MSN, CRNA, Kirk Lalwani, MD, FRCA, MCR 50. A Needle And The Damage Done Fatal Forty DDI: buprenorphine, ritonavir, CYP3A4 James Hilliard, MSN, CRNA, Kirk Lalwani, MD, FRCA, MCR 51. Dad's Not Having Much Pain Fatal Forty DDI: methadone, ciprofloxacin, CYP3A4 Rani Chovatiya, MD, Mehmet S. Ozcan, MD, FCCP, Randal O. Dull, MD, PhD 52. Royal Flush Fatal Forty DDI: methadone, nortriptyline, CYP2D6, CYP3A4 Kimberly Mauer, MD, Catherine Marcucci, MD, Neil B. Sandson, MD 53. The Worry That's Always With Us: Afternoon Nap oxycodone, diazepam Syed M. Quadri, DO, Randal O. Dull, MD, PhD 54. The Bawling Baby Fatal Forty DDI: rifampin, methadone , CYP3A4, CYP2B6 Angela Kendrick, MD 55. Sleeping Beauty Fatal Forty DDI: fentanyl, ritonavir, CYP3A4 Hans P. Sviggum, MD, Juraj Sprung, MD, PhD 56. Codeine Can't Do It Fatal Forty DDI: codeine, fluoxetine, CYP2D6 Katarina Bojanic, MD, Wayne T. Nicholson MD PharmD, MSc, Erica D. Wittwer MD, PhD, Toby N. Weingarten MD, Juraj Sprung, MD, PhD 57. A Shuddering Interaction meperidine, phenelzine, serotonin toxicity Christine A. Kenyon Laundre, MD, Randall Flick, MD, Juraj Sprung, MD, PhD 58. Double Indemnity Fatal Forty DDI: morphine, rifampin, P-glycoprotein Lisa Chan, MD, Catherine Marcucci, MD, Neil B. Sandson, MD, Kirk Lalwani, MD, FRCA, MCR 59. Breaking the Codeine Fatal Forty DDI: codeine, quinidine CYP2D6 Clint Christensen, MD, Nathan G. Orgain, MD, Randal O. Dull, MD, PhD 60. The Ultimate Ultram Primer I: My Mood Is Better, But Boy Do I Hurt! Fatal Forty DDI: tramadol, paroxetine, CYP2D6 Toby N. Weingarten MD, Juraj Sprung, MD, PhD 61. The Ultimate Ultram Primer II: I "Haight" Narcotics But I Hate Seizures Worse Fatal Forty DDI: tramadol, buproprion, seizures, CYP2D6 Bruce T. Dumser, MD, Neil B. Sandson, MD 62. The Ultimate Ultram Primer III: Tremor-dol Trigger in Serotonin Syndrome Fatal Forty DDI: tramadol, paroxetine, 2D6 inhibition, serotonin syndrome Bryan C. Hoelzer, MD, Stephanie Neuman, MD 63. Too Much of A Good Thing Fatal Forty DDI: codeine, drug-gene interaction, CYP2D6 Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson MD, PharmD, MSc Part VIII. Drug-Drug Interactions Involving Non-opioid Pain Medications 64. Introduction Toby N. Weingarten, MD 65. Pining For Pete In The Pain Clinic Fatal Forty DDI: nortriptyline, paroxetine, CYP2D6 Steven S. Liu, MD, Toby N. Weingarten MD, Catherine Marcucci, MD 66. You Do Not Look Well Today, Mon Ami Fatal Forty DDI: amitriptyline, amiodarone, QRS widening Kimberly Mauer, MD, Catherine Marcucci, MD, Neil B. Sandson, MD 67. My Headache is Gone, But My Leg Now Hurts Fatal Forty DDI: methysergide, erythromycin, CYP3A4 Jessica D. Lorenz, MD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 68. Special 'K'ase Oral S-ketamine, ticlopidine Lisa Chan, MD, Kirk Lalwani, MD, FRCA, MCR 69. Not Manic About NSAIDs Fatal Forty DDI: ketorolac, lithium, toxicity Allen N. Gustin, MD, FCCP, Michael J. Bishop, MD 70. Keep It Capped! acetominophen, ethanol Christine M. Formea, PharmD, BCPS, Wayne T. Nicholson MD, PharmD, MSc 71. The ACE Is Not Always High Fatal Forty DDI: ketorolac, lisinopril Wayne T. Nicholson, MD, PharmD, MSc 72. When The Smoke Clears, Relaxation Disappears Fatal Forty DDI: cyclobenzaprine, smoked tobacco, CYP1A2 Avinash Ramchandani, MD, Julio A. Gonzalez-Sotomayor, MD 73. Befuddled by Aspirin Fatal Forty DDI: aspirin, valproic acid, protein binding Melisa N. Weingarten, RN, MS, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD 74. You Can't Trick Us! Fatal Forty DDI: ibuprofen, phenytoin, CYP2C9, protein binding Catherine Marcucci, MD, Neil B. Sandson, MD Part IX. Drug-Drug Interactions Involving Benzodiazepines and Other Sedatives 75. Introduction Catherine Marcucci, MD 76. The Worry That's Always With Us: Now I'm Depressed benzodiazepines, opioids, propofol Kelly T. Peretich, MD, Raymond M. Planinsic, MD 77. The Worry That's Always With Us: Tragic But Not Rare alprazolam, clonazepam, and buprenorphine Phillip Adams, DO, Ibtesam A. Hilmi, MB, CHB, FRCA 78. Lack of Sedation Fatal Forty DDI: midazolam, carbamazepine interaction, CYP3A4 Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 79. A Cold Isn't Going to Slow Me Down midazolam, goldenseal, CYP3A4, CYP3A5, CYP2D6 Leelee Thames, MD, Jessica Miller, MD, BM 80. Her Patients Never Wake Up On Time Fatal Forty DDI: midazolam, diltiazem, alfentanil, CYP3A4, CYP3A5, CYP3A7 Toby N. Weingarten, MD, Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 81. When Enough Is Now Too Much Fatal Forty DDI: midazolam, itraconazole, CYP3A4 Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 82. The Distressed Daughter Fatal Forty DDI: alprazolam, carbamazepine, CYP3A4 Jennifer Egan, MD, Kirk Lalwani, MD, FRCA, MCR, Catherine Marcucci, MD 83. Check Check and Double Check Fatal Forty DDI: diazepam, fluvoxamine, CYP3A4, CYP2C19 Catherine Marcucci, MD, Neil B. Sandson, MD 84. Doggone It-The Case is Cancelled Fatal Forty DDI: midazolam, lopinavir/ritonavir, CYP3A4 Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Corinne Wisdo, DPM, Catherine Marcucci, MD 85. Noct' Out Fatal Forty DDI: chloral hydrate, phenobarbital, furosemide Michael Wollenberg, MD, Kirk Lalwani, MD, FRCA, MCR 86. Predisposed to Doze promethazine, CYP2D6 poor metabolizer Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson MD PharmD, MSc 87. Synergistic Sedation Fatal Forty DDI: midazolam, clozapine, synergism and clozapine, sertraline, CYP2D6 Michael Hutchens, MD, Paul Schipper, MD, FACS, FACCP, Catherine Marcucci, MD Part X. Drug-Drug Interactions Involving Neuromuscular Blockade Agents 88. Introduction David G. Metro, MD 89. Blocked Again succinylcholine, repeated doses Matthew Patrick Feuer, MD, Thomas M. Chalifoux, MD 90. Irreversibility Sux succinylcholine, neostigmine Joseph C. Shy, MD, David G. Metro, MD 91. Keep An "Ion" The Twitches magnesium, neuromuscular blockade Brian Gierl, MD, Ferenc E. Gyulai, MD 92. A Reversal of Misfortune neostigmine, glycopryrolate, Thomas N. Talamo, MD, Richard J. Kuwik, MD 93. Stop Moving Fatal Forty DDI: vecuronium, phenytoin Michael D. Olson, PA-C, Randall Flick, MD 94. There's Just Not Enough Roc In The World Fatal Forty DDI: rocuronium, carbamazepine Tammara S. Goldschmidt, MD, Randal O. Dull, MD, PhD 95. Slow Sux I: A Lengthy Wake-Up Period After Electroconvulsive Therapy succinylcholine, atypical plasma cholinesterase Jennifer A. Rabbitts, MB, ChB, Juraj Sprung, MD, PhD 96. Slow Sux II: I Remember Reviewing This For The Boards succinylcholine, atypical plasma cholinesterase Andrew Oken, MD, Scott Richins, MD 97. Slow Sux III: Where Did the Twitches Go? succinylcholine, donepizil, atypical pseudocholinesterase Katarina Bojanic, MD, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD 98. Weakened All Weekend vecuronium, amakacin Daniel W. Johnson, MD 99. The Patient Who Could Not Raise Her Head vecuronium, gentamicin Nicole L. Varela, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 100. An Unexpected Wait pancuronium,mivacurium Michael W. Best, MD, Shawn T. Beaman, MD 101. Diabolical Cough Syrup rocuronium, pholcodine Melisa N. Weingarten, RN, MS, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD Part XI. Drug-Drug Interactions Involving Antibiotics and Antifungals 102. Introduction Catherine Marcucci, MD 103. Full Stop ceftriaxone, calcium Norah Janosy, MD 104. Flummoxed by the FLOX Fatal Forty DDI: ciprofloxacin, tizanidine, CYP1A2 Janice Kim, MD 105. Tales of Terror Fatal Forty DDI: ciprofloxacin, simvastatin, CYP3A4 Arun Subramanian, MBBS, Juraj Sprung, MD, PhD 106. Too Low To Go Fatal Forty DDI: erythromycin, nifedipine, CYP3A4 Catherine Marcucci, MD, Neil B. Sandson, MD 107. A Fungal Story Fatal Forty DDI: fluconazole, phenytoin, CYP2C9, CYP2C19 Jerusha Taylor, PharmD, BCPS, Ansgar M. Brambrink, MD, PhD 108. Rejection Protection Turned Kidney Killer Fatal Forty DDI: voriconazole, tacrolimus, CYP3A4, P-glycoprotein Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Christine M. Formea, PharmD, BCPS 109. Can't Get Well Fatal Forty DDI: itraconazole, budesonide, CYP3A4 Michael J. Sikora, MD, Barbara Jericho, MD, Randal O. Dull, MD, PhD 110. Linezolid (I): Be VREy Careful Fatal Forty DDI: linezolid, buproprion Bruce T. Dumser, MD 111. Linezolid (II): Hyper and Hot linezolid, meperidine, serotonin syndrome Erica D. Wittwer, MD, PhD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 112. Not Sweet At All Fatal Forty DDI: trimethoprim/sulfamethoxazole, glipizide, CYP2C9 Mayumi Horibe, MD, Michael J. Bishop, MD 113. Where Did All The Sugar Go? Fatal Forty DDI: levofloxacine, glyburide, complex interaction Nicole L. Varela, MD, Federica Scavonetto, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 114. Exposed! (Part 1) Fatal Forty DDI: rifampin, buspirone, CYP3A4 L. Michele Noles, MD, Catherine Marcucci, MD 115. Exposed! (Part 2) Fatal Forty DDI: rifampin, ondansetron, CYP3A4 L. Michele Noles, MD, Catherine Marcucci, MD 116. Seizures on 5 West carbapenem, valproic acid, P-glycoprotein, UGT Elizabeth Duggan, MD, Nabil M. Elkassabany, MD Part XII. Drug-Drug Interactions Involving Cardiovascular Medications 117. Introduction Michael Hutchens, MD 118. Riding The Rollercoaster nitroglycerine, sodium nitroprusside, propofol, Catherine Marcucci, MD, Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD 119. A Pressing Need For Vasopressin! ACE-Is, general anesthesia Erin B. Payne, MD, Anna Dubovoy, MD 120. Too Young To Die Fatal Forty DDI: bupropion, pseudoephedrine, pharmacodynamic interaction Catherine Marcucci, MD 121. A Widening Gyre epinephrine, phosphorus, insulin Edward A. Kahl, MD, Michael Hutchens, MD 122. Misusing Mom's Meds chronic amphetamine, indirect acting sympathomimetics Pulsar Li, DO, Steven L. Orebaugh, MD 123. If the Patient Has No Renal Failure, Why is Her Potassium So High? candesartan, spironolactone, Jennifer A. Rabbitts, MB, ChB, Wayne T. Nicholson, MD, PharmD, MSc, Juraj Sprung, MD, PhD 124. Prazosin and the PTSD Paratrooper prazosin, tadalafil, Allen N. Gustin, MD, FCCP, Michael J. Bishop, MD 125. Nicardipine Notes Fatal Forty DDI: nicardipine, tacrolimus, CYP3A4 Nenna Nwazota, MD, Randal O. Dull, MD, PhD 126. Hypotension Harry Fatal Forty DDI: nicardipine, clarithromycin, CYP3A4 Matthew Hart, MSN, CRNA, Bryan J. Read, MSN,CRNA, Wayne T. Nicholson, MD, PharmD, MSc, Toby N. Weingarten, MD 127. Too Slow to Flow Fatal Forty DDI: CYP2D6 ultraslow metabolism of metoprolol Scott W. Cantwell, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 128. Better Sleep But Slower Heart metoprolol, diphenhydramine, CYP2D6 Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD 129. Extreme Blood Pressure After Ephedrine: Should We Rule Out Pheochromocytoma? ephedrine, selegiline Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 130. Heart-Stopping Treatment Fatal Forty DDI: verapamil, erythromycin, CYP3A4 Erica D. Wittwer, MD, PhD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 131. Induction Crashes: Are There Clues In the Ashes? Fatal Forty DDI: theophylline, smoked tobacco, CYP1A2 Dawn L. Baker, MD, MS, L. Lazarre Ogden, MD 132. The Wakeup Call: 2AM Trauma beta blockers, cocaine Devin C. Tang, MD, Nabil M. Elkassabany, MD 133. Falling Down Fatal Forty DDI: nifedipine, fluoxetine, CYP3A4 Scott Kennedy, MD, Norman A. Cohen, MD 134. A Hidden Drug Fatal Forty DDI: diltiazem, sildenafil, CYP3A4 and sildenafil, nitroglycerin Helga Komen, MD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 135. I'm Listening, I'm Listening Fatal Forty DDI: diltiazem, carbamazepine, CYP3A4 Catherine Marcucci, MD, Jerusha Taylor, PharmD, BCPS, Ansgar M. Brambrink, MD, PhD, Neil B. Sandson, MD 136. Jump Start My Heart metoprolol, amiodarone , CYP2D6, CYP1A2 Katarina Bojanic, MD, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD 137. The Statin Trilogy (I): 'Statin' From The Beginning Fatal Forty DDI: simvastatin, cimetidine, diltiazem, CYP3A4 Brian Mitchell, MD 138. The Statin Trilogy (II): Tripped And Fell At The Train 'Statin' Fatal Forty DDI: simavastatin, itraconazole, CYP3A4 Brian Mitchell, MD 139. The Statin Trilogy (III): Welcome To The United 'Statins' Of America Fatal Forty DDI: atorvastatin, phenytoin, CYP3A4 Brian Mitchell, MD 140. Be Still, My Beating Heart Fatal Forty DDI: amiodarone, digoxin, P-glycoprotein Branka Polic, MD, MSc, Julije Mestrovic, MD, PhD, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 141. The Nice Niece digoxin, St. John's wort, CYP3A4, P-glycoprotein Michael Hutchens, MD, Catherine Marcucci, MD 142. Cyclo Killer: Qu'est-ce que c'est? carvedilol, cyclosporine, P-glycoprotein Jeff Chen, MD, Michael Hutchens, MD, Wayne T. Nicholson MD, PharmD, MSc 143. Blurry-Eyed With Rapid Heart Beats Fatal Forty DDI: digoxin, hydrochlorothiazide, William A. Shakespeare, MD, Juraj Sprung, MD, PhD Part XIII. Drug-Drug Interactions Involving Coagulation Modifiers 144. Introduction Catherine Marcucci, MD 145. Seize the Day Fatal Forty DDI: tranexamic acid, furosemide, ibuprofen Roman M. Sniecinski, MD, Erica D. Wittwer, MD, PhD, Kenichi Tanaka, MD, MSc, James Zaidan, MD 146. The Third and Final Complication Fatal Forty DDI: warfarin, nafcillin Daniel W. Johnson, MD 147. An Interaction With the Furniture Fatal Forty DDI: warfarin, metronidazole, ciprofloxacin, CYP2C9, CYP1A2 Heather Norvelle, PharmD, BCPS, Ines P. Koerner, MD, PhD 148. Macrolide Mishap for Little Miss Muffett Fatal Forty DDI: warfarin, clarithromycin, CYP2C9 Elizabeth Pedigo, MD 149. From Asymptomatic to Symptomatic: a Cause of Nosebleed Fatal Forty DDI: warfarin, amiodarone, CYP2C9 Josko Markic, MD, MSc, Julije Mestrovic, MD, PhD, Juraj Sprung, MD, PhD 150. The Consequences of Not Following A Cardiac Diet Fatal Forty DDI: clopidogrel, omeprazole, CYP2C19 Kristen B. McCullough, PharmD, BCPS, BCOP, Wayne T. Nicholson, MD, PharmD, MSc 151. Clopidogrel (I): Bagel Brunch Fatal Forty DDI: clopidogrel, omeprazole, CYP2C19 Ann Marie Canelas, MD, Randal O. Dull, MD, PhD 152. Clopidogrel (II): Conferring Over The Kung Pao clopidogrel, proton pump inhibitors, calcium channel blockers, CYP2C19, CYP3A4 Catherine Marcucci, MD, Neil B. Sandson, MD Part XIV. Drug-Drug Interactions Involving Immunosuppressants, Antiemetics, and Chemotherapy 153. Introduction Catherine Marcucci, MD 154. Beaned Fatal Forty DDI: diltiazem, tacrolimus, CYP3A4, P-glycoprotein Matthew Hart, MSN, CRNA, Michael Hutchens, MD 155. Addisonian Adjustment Fatal Forty DDI: prednisone, fluconazole, CYP3A4 Catherine Marcucci, MD, Neil B. Sandson, MD 156. Tea Time Fatal Forty DDI: St. John's Wort, tacrolimus, cyclosporine, CYP3A4, P-glycoprotein Nikki Jaworski, MD 157. No Fits at Uffizi Fatal Forty DDI: phenytoin, cyclosporine, CYP3A4 Michael Hutchens, MD, Christine M. Formea, PharmD, BCPS 158. Quit Steroids Quit Kidneys steroid, tacrolimus, CYP3A, P-glycoprotein Toby N. Weingarten, MD, Wayne T. Nicholson, MD, PharmD, MSc, Christine M. Formea, PharmD, BCPS 159. The Fall Guy (I) Fatal Forty DDI: tamoxifen, metoclopramide, CYP2D6 Catherine Marcucci, MD, Neil B. Sandson, MD 160. The Fall Guy (2) Fatal Forty DDI: tamoxifen, diphenhydramine, CYP2D6 Catherine Marcucci, MD, Neil B. Sandson, MD 161. The Topic of the Day Fatal Forty DDI: cimetidine, lidocaine, CYP1A2, CYP3A4 Catherine Marcucci, MD 162. Bounce Back ondansetron, CYP2D6 ultrarapid metabolism Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc, Juraj Sprung, MD, PhD 163. Call The Cath Lab! Fatal Forty DDI: omeprazole, clopidogrel, CYP2C19 Anna Dubovoy, MD, Erin B. Payne, MD 164. The Imatinib Inquiry: A Theoretical Case (For Now) imatinib, metoprolol, midazolam, fentanyl, CYP3A4 Stephen J. Gleich, MD, Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Nicole Henwood, MD 165. A HAART-Breaking Tale metformin, tenofovir Dean Laochamroonvorapongse, MD, Kirk Lalwani, MD, FRCA, MCR Part XV. Drug-Drug Interactions Involving Neuropsychiatric Drugs 166. Introduction Neil B. Sandson, MD 167. Phenytoin (I): Going Crazy! Fatal Forty DDI: phenytoin, quetiapine, CYP3A4 Sara M. Skrlin, MD, Ansgar M. Brambrink, MD, PhD 168. Phenytoin (II): The Wrong Drug for the Schizophrenic Fatal Forty DDI: phenytoin, quetiapine, CYP3A4 Melisa N. Weingarten, RN, MS, Juraj Sprung, MD, PhD, Toby N. Weingarten, MD 169. Dizzy and Depressed Fatal Forty DDI: nefazodone, carbamazepine, CYP3A4 William A. Shakespeare, MD, Juraj Sprung, MD, PhD 170. The Funeral Is On Monday Fatal Forty DDI: phenytoin, valproic acid, CYP2C9 Elizabeth Macri, MD, Ansgar M. Brambrink, MD, PhD, Neil B. Sandson, MD 171. This Antacid Is Making Me Sick! Fatal Forty DDI: phenytoin, cimetidine, CYP2C9, CYP2C19 Arun Subramanian, MBBS, Toby N. Weingarten MD, Juraj Sprung, MD, PhD 172. Young at Heart Fatal Forty DDI: pimozide, nefazodone, CYP3A4 Catherine Marcucci, MD 173. Shiver Yes, Die No - selegiline patch, meperidine, serotonin syndrome Ahmed F. Zaky, MD, MPH, Michael J. Bishop, MD 174. Clip and Dip Fatal Forty DDI: carbamazepine, felodipine, CYP3A4 David W. Barbara, MD, Randall Flick, MD, Juraj Sprung, MD, PhD 175. Blue Fog citalopram, methylene blue, serotonin syndrome Toby N. Weingarten, MD, Wayne T. Nicholson, MD, PharmD, MSc, Juraj Sprung, MD, PhD 176. Confiscated Contraceptives Fatal Forty DDI: lamotrigene, ethinylestradiol, UGT1A4 Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD PharmD, MSc 177. Gotta Love Derm Fatal Forty DDI: lamotrigine, valproic acid, UGT1A4 Jonathan Anson, MD, Richard C. Month, MD 178. Desperate for A Drink Fatal Forty DDI: amitriptyline, CYP2D6 poor metabolizer Erica D. Wittwer, MD, PhD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc Part XVI. Drug-Drug Interactions Involving QT Prolonging DDIs 179. Introduction Matthew DeCaro, MD, FACC, FACP 180. Delusion At Heart Fatal Forty DDI: thioridazine, ondanestron, QT-prolongation Arun Subramanian, MBBS, Toby N. Weingarten, MD, Juraj Sprung, MD, PhD 181. At Long Last Fatal Forty DDI: ziprasidone, moxifloxacin, CYP3A4, CYP2D6, QT-prolongation, Kristen B. McCullough, PharmD, BCPS, BCOP, Wayne T. Nicholson, MD, PharmD, MSc 182. Metha-don't! Fatal Forty DDI: methadone, amitriptyline, levofloxacin, CYP2D6 , QT-prolongation Bryan C. Hoelzer, MD, Juraj Sprung, MD, PhD, Wayne T. Nicholson, MD, PharmD, MSc 183. Flash Fire amiodarone, haloperidol, CYP1A2, CYP3A4, CYP2D6, QT-prolongation, Michael Hutchens, MD, Catherine Marcucci, MD, Neil B. Sandson, MD 184. I Am Dizzy When I Stand Up Fatal Forty DDI: thioridazine, propranolol, CYP2D6, QT-prolongation, Tasha L. Welch, MD, Toby N. Weingarten, MD, Juraj Sprung MD, PhD Part XVII. Drug-Drug Interactions Involving Foods and Nutrition 185. Introduction Kevin W. Cleveland, PharmD, David G. Metro, MD 186. High Fat Diet (I): No Juice For The Ketotic Kid ketosis, carbohydrates, seizures Denise M. Hall Burton, MD, Miya Asato, MD, Charles Boucek, MD 187. Protein Huffing and Puffing theophylline, dietary protein, CYP1A2 Brian C. Bane, MD, James Gordon Cain, MD, MBA, FAAP 188. Salty Sam high salt diet, nitroprusside Robert Scott Lang, MD, Li Meng, MD, MPH 189. A Peak Potassium Problem salt substitute, spironolactone, lisinopril Justin McCray, MD, Steven L. Orebaugh, MD 190. Awake? vitamin C, general anesthetics Nicole Scouras, MD, David G. Metro, MD 191. Tropical Punch Packing a Real Knockout Fatal Forty DDI: grapefruit juice, midazolam, CYP3A4 Brian Blasiole, MD, PhD, Shawn T. Beaman, MD 192. When The Fire Won't Go Out pomegranate juice, sildenafil, CYP3A4 Thomas P. Pontinen, MD, Randal O. Dull, MD, PhD 193. Peppermint Patty Fatal Forty DDI: peppermint, felodipine, CYP3A4 Ryan D. Ball, MD, Karen Boretsky, MD 194. From Bleeding Gums to Green Thumbs- A True Story Fatal Forty DDI: warfarin, green vegetables Audra M. Webber, MD, Patricia L. Dalby, MD 195. Delicious but Malicious licorice, spironolactone, hypokalemia Eric Fox, BA, Kirk Lalwani, MD, FRCA, MCR 196. I Just Can't Lick This Problem Fatal Forty DDI: licorice, electrolytes, digoxin Koshy M. Mathai, MD, Michael Hutchens, MD, Robert G. Krohner, MD 197. Sommelier's Surprise tyramine rich foods, MAO-i drugs, monoamine oxidase Charles Lin, MD, Joseph F. Talarico, DO 198. Dairy Carefully Fatal Forty DDI: dairy, fluoroquinolone Kristin Ondecko Ligda, MD, Erin A. Sullivan, MD 199. Cold And Sick, Sick And Cold fiber, thyroxine replacement, malabsorption A. Murat Kaynar, MD, MPH, Nikhil K. Bhatnagar, MD 200. TPN (I): A Review and Two Interactions TPN basics and complications Lavinia Kolarcyzk, MD, Patrick J. Forte, MD 201. TPN (II): A Traumatic Case of Increased Metabolism TPN, valproic acid Erica D. Wittwer, MD, PhD, Wayne T. Nicholson, MD, Pharm D, MSc, Juraj Sprung, MD, PhD 202. Skin and Bones starvation, perioperative drugs Mariam M. El-Baghdadi, MD, Ibtesam A. Hilmi, MB, CHB, FRCA 203. Enough to Make You Sick syrup of ipecac, general anesthesia John Hache, MD, Thomas M. Chalifoux, MD 204. Determined and Desperate to Diet Fatal Forty DDI: Orlistat, warfarin Lisa Chan, MD, Kirk Lalwani, MD, FRCA, MCR Part XVIII. Drug-Drug Interactions Involving Spices and Supplements 205. Introduction Kirk Lalwani, MD, FRCA, MCR 206. Caffeine Crash Fatal Forty DDI: caffeine, ethinylestradiol, ciprofloxacin, CYP1A2 Brian Gierl, MD, Ryan Romeo, MD 207. Sad Sequelae Fatal Forty DDI: Dong quai, warfarin Stacy L. Fairbanks, MD 208. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Seizures Ginkgo biloba, phenytoin, CYP2C19 Shreya Patel, MD, Kirk Lalwani, MD, FRCA, MCR 209. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Sugar Ginkgo biloba, tolbutamide, CYP2C9 Shreya Patel, MD, Kirk Lalwani, MD, FRCA, MCR 210. The Scary Side of Ginkgo Biloba Is No Match For An Anesthesia Superstar: Subdural Ginkgo biloba Shreya Patel, MD, Kirk Lalwani, MD, FRCA, MCR 211. "Khat" Unawares depletion of central and peripheral endogenous catecholamines Brian D. Tompkins, MD, Kirk Lalwani, MD, FRCA, MCR 212. Pain on the Plane Fatal Forty DDI: ginseng, warfarin, CYP2C9 Lei Wu, MD, Kirk Lalwani, MD, FRCA, MCR 213. Ca va, c'est Kava kava,carbidopa-levodopa, dopamine receptors Solina Tith, MD, Kirk Lalwani, MD, FRCA, MCR 214. Summertime and the Herbals are Hot Fatal Forty DDI: goldenseal, amitriptyline CYP2D6, CYP3A4 Jessica Miller, MD, BM, Leelee Thames, MD 215. Garlic I: More Than Just Bad Breath Fatal Forty DDI: garlic, ritonavir, CYP3A4, P-glycoprotein Vincent Lew, MD, Kirk Lalwani, MD, FRCA, MCR 216. Garlic II: A Girl Named Allicin garlic, inhibition of clotting cascade Vincent Lew, MD, Kirk Lalwani, MD, FRCA, MCR 217. "Danshen" the Night Away Fatal Forty DDI: Salvia miltiorrhiza, warfarin, CYP2C9, CYP1A2 Tara C. Carey, BA, MD, Kirk Lalwani, MD, FRCA, MCR 218. Caught Yellow-Handed Fatal Forty DDI: tumeric, warfarin, CYP1A2, CYP2C9 Giorgio Veneziano, MD, Michael Mangione, MD 219. St. John: Not Such A Saint Fatal Forty DDI: St. John's Wort, cyclosporine, CYP3A4, P-glycoprotein Heather Norvelle, PharmD, BCPS, Ines P. Koerner, MD, PhD 220. Hearing the News Fatal Forty DDI: St. John's Wort, oral contraceptives, CYP3A4, P-glycoprotein Nikki Jaworski, MD

Product Details

  • publication date: 16/09/2015
  • ISBN13: 9781461474944
  • Format: Paperback
  • Year: 2015
  • Number Of Pages: 1064
  • ID: 9781461474944
  • weight: 1597
  • ISBN10: 1461474949

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