In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of the scientific world. Upon reading Bateson's paper, Archibald Garrod realized the relevance of Mendel's laws to human disease and in 1902 introduced Mendelism to medical genetics. The first part of A Century of Mendelism in Human Genetics takes a historical perspective of the first 50 years of Mendelism, including the bitter argument between the Mendelians and the biometricians. The second part discusses human genetics since 1950, ending with a final chapter examining genetics and the future of medicine. The book considers the genetics of both single-gene and complex diseases, human cancer genetics, genetic linkage, and natural selection in human populations.
Besides being of general medical significance, this book will be of particular interest to departments of genetics and of medical genetics, as well as to historians of science and medicine.
THE FIRST FIFTY YEARS OF MENDELISM The Introduction of Mendelism into Human Genetics Galton's Theory of Ancestral Inheritance The Reception of Mendelism by the Biometricians and the Early Mendelians Mendelism and Man 1918 - 1939 The Darwin Lecture: William Bateson, Archibald Garrod and the Nature of the "Inborn" HUMAN GENETICS FROM 1950 Linkage and Allelic Association Malaria and Darwinian Selection in Human Populations Chromosomal Genetics and Evolution Mendelian Disorders in Man: The Development of Human Genetics The Genetics of Complex Diseases Human Cancer Genetics Genetics and the Future of Medicine APPENDIX