Using the published work of Nobel Laureate Niels Kaj Jerne, this book shows how he developd his ideas. The book is a compilation of his published work, but in fact it is much more than that. Whether the reader wants to read the book systematically, or only browse, it opens a fascinating world of hypotheses, theories, facts and vistas. His selection theory, his view of how immunological diversity is created, and his concept of lymphocytes interacting as a network, reveals Jerne's revolutionary spirit. The book ought to be a rich source of inspiration for everyone interested in science and how science is made.
A study of avidity based on rabbit skin responses to diphtheria toxin-antioxin mixtures, N.K. Jerne; the natural-selection theory of antibody formation, N.K. Jerne; immunological speculations, N.K. Jerne; plaque formation in agar by single antibody-producing cells, N.K. Jerne and A.A. Nordin; the natural selection theory of antibody formation; ten years later, in "Phage and the Origins of Molecular Biology", N.K. Jerne; the somatic generation of immune recognition, N.K. Jerne; the immune system, N.K. Jerne; towards a network theory of the immune system, N.K. Jerne; idiotypic networks and other preconceived ideas, N.K. Jerne; the generative grammar of the immune system, N.K. Jerne; and other papers.