This book is a practical guide for those engaged in small-molecule combinatorial chemistry as well as those wishing to learn the field. Aimed at nonspecialists, the chapters are written in a tutorial style by internationally recognized experts. The text reviews the use of computational tools to analyse molecular diversity and presents a detailed survey of solid-phase peptide synthesis and the tools used for small-molecule synthesis. Up-to-date automated approaches and equipment for synthesizing solid- and solution-phase libraries are reviewed, including synthesis, analytical, and deconvolution tools. This book will be useful to medicinal chemists, organic chemists, biochemists engaged in high-throughput screening, materials scientists, patent professionals, and science writers.
1. Introduction: Combinatorial Chemistry Approaches the Next Millenium ; 2. Using Computational Tools to Analyze Molecular Diversity ; SOLID-PHASE STRATEGIES ; 3. Solid Phase Synthesis: Context ; 4. Synthesis Tools for Solid-Phase Synthesis ; 5. On-Resin Analysis in Combinatorial Chemistry ; 6. Deconvolution Tools for Solid-Phase Synthesis ; SOLUTION-PHASE STRATEGIES ; 7. Synthesis Tools for Solution-Phase Synthesis ; 8. Analytical Tools for Solution-Phase Synthesis ; 9. Deconvolution Tools in Solution-Phase Synthesis ; EQUIPMENT AND AUTOMATION ; 10. Equipment for the High Throughput Organic Synthesis of Chemical Libraries ; 11. Automated Approaches to Reaction Optimization ; 12. Application of Automated Parallel Synthesis ; INFORMATION MANAGEMENT AND BIOLOGICAL APPLICATIONS ; 13. Information Management ; 14. Screening of Combinatorial Libraries ; 15. Summary
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- ID: 9780841234857
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