Recognition of adaptive processes in biological systems as a discipline is still in its infancy. It is known that repeat exposure to low level stresses such as heat, cold, microgravity, hypoxia, exercise, etc. increases body-resistance to not only the particular stress but also to other conditions. Such a cross-protection can be utilized in a better patient care. This volume describes most current developments in the understanding of the molecular basis of adaptation as well as its application in biological systems including certain disease conditions in humans. The book is based on the presentations made by internationally known experts assembled in San Diego, USA for the 7th World Congress of the International Society for Adaptive Medicine and will be of great interest to experimental biologists as well as clinicians who deal with a wide variety of clinical conditions.
A. Hargens.: Department of Orhtopaedics, University of California San Diego 92103-8894, U. S. A N. Takeda.: Department of Internal Medicine, Aoto Hospital Jikei University School of Medicine, Tokyo, Japan P.K. Singal.: Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre University of Manitoba, Winnipeg, Canada
Preface/ Acknowledgments/ Contributing Authors/ Novel approaches to the Understanding of Molecular Mechanisms of Adaptation/ Responses of the Inbred Fok Rat to Ambient Heat and Cold/ Distinction Between Stress Resistance and Protective Effects of Adaptation in Rats of Different Genetic Strains: Role of Regulatory Systems/ The Mechanisms of Hypoxytherapy and the Basis of Resonant Normobaric Hypoxytherapy/ Contribution of Sarcolemmal Ca2+ -ATPase to Free Shortening and Its Energy Expenditure for Excitation-Contraction Coupling in Rat Ventricular Slices/ Cardiovascular Adaptation to Gravity: Lessons from Comparative Studies of Snakes/ Role of Free NO and NO Stores in Protective Effects of Adaptation due to Hypoxia/ The Thioredoxin-Thioredoxin Reductase System Adapts to Human Cancer Growth by Overexpression/ Membranoprotective Effects of Adaptation in the Heart and Skeletal Muscle/ Ingesting Only Glucose: Behavioral Adaptation to Lessen High Altitude Pulmonary Edema/ Lower Body Negative Pressure Treadmill Exercise Counteracts Deconditioning of Lumbar Spine during 30 Days of Bed Rest/ Activation of Protein Kinases and Cellular Redistribution of Inducible HSP70 Protein in Chronically Hypoxic Infant Human and Rabbit Hearts: Role in Cardioprotection/ Hypoxic Therapy of Cardiovascular Diseases/ Autoimmunity and Risk Factors in Atherosclerosis/ Prospects for Using Methods of Adaptive Medicine in Alzheimer's Disease/ Adaptation to Radiation and Combined Impacts/ Role of Renin-Angiotensin System in the Development of Cardiac Hypertrophy and Heart Failure/ Spinal Muscle Activation with the Keiser Variable Resistance Device for Space Flight Compared to Standard Earth-Based Weight Devices/ Induction of the Heat Shock Protein in Rat Lungs following Intermittent Hypoxic Training/ Role of Oxidative Stress in Enhanced Expression of Gia Proteins and Adenylyl Cyclase Signalling/ Resistance to Glucose-Induced Apoptosis: Possible Mechanisms/ Enhancing Mycardial Ischemic Tolerance via Adaptation to Acute Systemic Hypoxia: Pivotal Role of iNOS as the Trigger and Mediator/ Changes in the Electroretinogram during Ischemia-Reperfusion in Young and Aged Rats under Normothermic and Hypothermic Conditions/ Simultaneous Measurements of Cerebral and Muscle Oxygenation and Blood Volume Responses in Healthy Men During Exposure to Seated Whole-Body Vibration/ Vascular Adaptation to Microgravity: Role and Implications of Local Vascular Renin-Angiotensin System / Index