Molecular basis of gradual adaptation of body systems in stressful conditions is a great mystery of biology. Such an adaptation not only increases tolerance of the body to that given stress but also to other challenges. An understanding of this cross protection needs to be exploited to improve patient care. The book includes 25 chapters describing molecular, subcellular and organ biology. Although for an easy reading the information has been grouped under the sub-headings: Adaptation to Cardiovascular Stresses, Adaptation to Neurohumoral Stresses, Adaptation to Other Stresses, the book represents a common continuum of adaptations. The therapeutic value of the understanding of the science of adaptation has also been described in several chapters. Examples of cross adaptations are also provided, where repeated exposure to one stimulus may have applications in the treatment and prophylaxis of different diseases. The present book will be of great interest to all biologists, physiologists, pharmacologiss and physicians interested in the application of the biology of adaptation in the improvement of health.
L. Lukyanova.: Institute of General Pathology and Pathophysiology RAMS, Moscow, Russia N. Takeda.: Department of Internal Medicine, Aoto Hospital Jikei University School of Medicine, Tokyo, Japan P. K. Singal.: Professor of Physiology, Institute of Cardiovascular Sciences St. Boniface General Hospital Research Centre and Dept. of Physiology Faulty of Medicine, University of Manitoba Winnipeg, Canada
Dedication / Preface / Acknowledgments / Contributing Authors / Part A. Adaptation to Cardiovascular Stresses: Tyrosine kinases as upstream regulators of H2O2-induced signaling / Oxidative modulation of Angiotensin II-induced G-protein signaling in cardiovascular adaptations / Cardiovascular responses to lower body positive pressure / Nitric oxide synthase 3 mediates cardioprotection by hyperoxia and hyperbaria / Vascular nitric oxide: effects of physical activity, benefits for health / Intermittent hypoxia conditioning of canine myocardium: robust protection against ischemia-reperfusion injury / Acute heat shock treatment enhances cardiac tolerance to ischemia/reperfusion-induced damage / Adaptation of the heart to toxic action of Adriamycin / The activation of mitochondrial atp-dependent potassium channel is one of the mechanisms of adaptation to hypoxia / Part B. Adaptation to Neurohumoral Stresses: Characteristics of cholinergic and cognitive functions in rats with individual resistance to the cerebral ischemia / Adaptation to stress in physical and mental illness / Resistance to stress and neurodegenerative damage in rats of different genetic strains. Protective effects of adaptation to hypoxia / The processes of adaptation of microglia in brain trauma and metastasis / Genetic peculiarities of neurohumoral regulation and resistance to stress damages / Hypothalamic Chemical Mechanisms of Resistance to Emotional Stress / Physiological significance of endogenous satiety substances during food intake / Part C. Adaptation to Other Stresses: Clinicopathological aspects and risk factors of breast cancer: adaptation of biological aggressive carcinomas in young arab women / Mitochondrial signaling in adaptation to hypoxia / A virtual multicellular organism with homeostatic and adaptive properties / Nitric oxide (NO) in modulating hypoxia signal transmission / Mitochondrial proliferation as adaptation mechanism in various diseases / Increase in resistance of membrane structures in adaptation to changing oxygen level / Plant adaptogens activate cellular mechanisms by causing mild damage / Interactions between cytokines and protease inhibitors in the mechanisms responsible for thermoregulatory responses during systemic inflammation / Impairment of adaptive responses to heat exposure: aging and bacterial translocation / Facts that prove that adaptation to life at extreme altitude (8848m) is possible / Index.