Adhesion Molecules and Chemokines in Lymphocyte Trafficking
By: Alf Hamann (author)Hardback
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This volume highlights the functional role of adhesion molecules and chemokines in interactions between lymphocytes and endothelium, regulating recirculation and homing. It reviews key topics such as the principles of lymphocyte-endothelium interactions, lymphocyte recruitment into tumours and inflamed tissues, and the medical prospects of these molecules for tumour immunotherapy.
Specific trafficking - which cells, which function?; lymphocyte traffic to lymphoid and non-lymphoid organs in different species is regulated by several mechanisms; the multistep paradigm and the control of lymphocyte trafficking - homing to mucosal tissues as a model; adhesion molecules and the regulation of the migration of lymphocytes; chemokines as regulators of leukocyte adhesion and migration; the ontogeny of lymphocytes and homing to the thymus; roles of a4b7 and aEb7 integrins in the interactions of lymphocytes with the intestinal mucosa; T cell trafficking to skin - a paradigm for tissue-selective lymphocyte homing; lymphocyte trafficking through the central nervous system.
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- ID: 9789057022289
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