Advances in Enzymology and Related Areas of Molecular Biology (Advances in Enzymology and Related Areas of Molecular Biology Volume 77)

Advances in Enzymology and Related Areas of Molecular Biology (Advances in Enzymology and Related Areas of Molecular Biology Volume 77)

By: Eric J. Toone (editor)Hardback

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This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes.

About Author

Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone has served as a member of the Bioorganic and Natural Products Study Section at the National Institutes of Health, and is currently a member of the NSERC Organic & Inorganic Review panel (Canada). Professor Toone is also the Deputy Director for Technology for the Advanced Research Projects Agency Energy (ARPA-E) of the Department of Energy and directs the ARPA-E's Electrofuels program.


Contributors. Preface. Structure and Mechanism of RND-Type Multidrug Efflux Pumps (Hiroshi Nikaido). Efflux Pumps of Gram-Negative Bacteria: Genetic Responses to Stress and the Modulation of Their Activity by pH, Inhibitors, and Phenothiazines (Leonard Amaral, Seamus Fanning, and Jean-Marie Pages). Efflux Pumps of the Resistance Nodulation Division Family: A Perspective of Their Structure, Function, and Regulation in Gram-Negative Bacteria (Mathew D. Routh, Yaramah Zalucki, Chih-Chia Su, Feng Long, Qijing Zhang, William M. Shafer, and Edward W. Yu). The MFS Efflux Proteins of Gram-Positive and Gram-Negative Bacteria (Massoud Saidijam, Kim E. Bettaney, Dong Leng, Pikyee Ma, Zhiqiang Xu, Jeffrey N. Keen, Nicholas G. Rutherford, Alison Ward, Peter J. F. Henderson, Gerda Szakonyi, Qinghu Ren, Ian T. Paulsen, Ingerid Nes, Jasmin K. Kroeger, and Anne-Brit Kolsto). Efflux Pumps as an Important Mechanism for Quinolone Resistance (Jordi Vila, Anna Fabrega, Ignasi Roca, Alvaro Hernandez, and Jose Luis Martinez). Xenobiotic Efflux in Bacteria and Fungi: A Genomics Update (Ravi D. Barabote, Jose Thekkiniath, Richard E. Strauss, Govindsamy Vediyappan, Joe A. Fralick, and Michael J. San Francisco). A Survey of Oxidative Paracatalytic Reactions Catalyzed by Enzymes That Generate Carbanionic Intermediates: Implications for ROS Production, Cancer Etiology, and Neurodegenerative Diseases (Victoria I. Bunik, John V. Schloss, John T. Pinto, Natalia Dudareva, and Arthur J. L. Cooper). Author Index. Subject Index.

Product Details

  • ISBN13: 9780470638354
  • Format: Hardback
  • Number Of Pages: 432
  • ID: 9780470638354
  • weight: 762
  • ISBN10: 0470638354
  • edition: Volume 77

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