This book provides up-to-date information on the crucial interaction of pathogenic bacteria and professional phagocytes, the host cells whose purpose is to ingest, kill, and digest bacteria in defense against infection. The introductory chapters focus on the receptors used by professional phagocytes to recognize and phagocytose bacteria, and the signal transduction events that are essential for phagocytosis of bacteria. Subsequent chapters discuss specific bacterial pathogens and the strategies they use in confronting professional phagocytes. Examples include Helicobacter pylori, Streptococcus pneumoniae, and Yersinae, each of which uses distinct mechanisms to avoid being phagocytosed and killed. Contrasting examples include Listeria monocytogenes and Mycobacterium tuberculosis, which survive and replicate intracellularly, and actually cooperate with phagocytes to promote their entry into these cells. Together, the contributions in this book provide an outstanding review of current knowledge regarding the mechanisms of phagocytosis and how specific pathogenic bacteria avoid or exploit these mechanisms.
Joel D. Ernst is the Director of the Division of Infectious Diseases and Professor of Medicine and Microbiology at the New York University School of Medicine. Olle Stendahl is Professor of Medical Microbiology at Linkoeping University, Sweden.
1. Introduction Olle Stendahl; 2. Phagocytosis: receptors and biology Wouter L. W. Hazenbos and Eric J. Brown; 3. Receptor-initiated signal transduction during phagocytosis Kassidy K. Huynh and Sergio Grinstein; 4. Life, death, and inflammation: manipulation of phagocyte function by Helicobacter pylori Lee-Ann H. Allen; 5. Phagocytosis of Streptococcus pneumoniae Dominic L. Jack, David H. Dockrell, Stephen B. Gordon and Robert C. Read; 6. Yersinia inhibition of phagocytosis Maria Fallman and Anna Gustavsson; 7. Listeria invasion and spread in nonprofessional phagocytes Frederick S. Southwick; 8. Mycobacterium tuberculosis: mechanisms of phagocytosis and intracellular survival Joel D. Ernst and Andrea Wolf.