Emerging evidence suggests that dendritic cells play a major role in the orchestration of the immune response to bacteria. This volume introduces the reader to the complex world of dendritic cells and describes how the intimate interplay between dendritic cells, bacteria and the environment dictates either the induction of immunity or tolerance to the encountered microorganisms. It discusses how this can allow organisms to tolerate beneficial bacteria and to react against pathogens, as well as the strategies pathogenic bacteria have evolved to escape dendritic cell patrolling. Expert contributors discuss everything from bacterial capture and recognition to their killing, processing and the induction of adaptive immunity. Particular focus is on the tissue context in which bacteria are handled by dendritic cells and on possible defects therein, which may potentially lead to chronic infection or inflammation. Graduate students and researchers will find this an invaluable overview of current dendritic cell biology research.
Maria Rescigno is the Director of the Research Unit at the European Institute of Oncology, Italy. The research focuses on the study of dendritic cell biology and immunotherapy.
Preface; Part I. Dendritic Cells and Their Role in Immunity: 1. Sub-populations and differentiation of mouse dendritic cells Carlos Ardavin; 2. Toll-like receptor signalling Osamu Takeuchia and Shizuo Akira; 3. MHC class I & II pathways for presentation and cross presentation of bacterial antigens Laurence Bougneres-Vermont and Pierre Guermonprez; Part II. Dendritic Cells and Innate Immune Responses to Bacteria: 4. Dendritic cell activation and uptake of bacteria in vivo Maria Rescigno; 5. Role of dendritic cells in the innate response to bacteria Natalya V. Serbina and Eric G. Pamer; 6. Interactions between natural killer and dendritic cells during bacterial infections Guido Ferlazzo; Part III. Dendritic Cells and Adaptive Immune Response to Bacteria: 7. Peculiar ability of dendritic cells to process and present antigens from vacuolar pathogens: a lesson from Legionella Sunny Shin, Catarina Nogueira and Craig R. Roy; 8. Dendritic cells, macrophages and cross-presentation of bacterial antigens: a lesson from Salmonella Mary Jo Wick; Part IV. Dendritic Cells and Immune Evasion of Bacteria in vivo: 9. Pathogen-recognition receptors as targets for pathogens to modulate immune function of antigen presenting cells Anneke Engering, Sandra J. van Vliet, Estella A. Koppel, Teunis B. H. Geijtenbeek and Yvette van Kooyk; 10. Suppression of immune responses by bacteria and their products through dendritic cell modulation and regulatory T cell induction Miriam T. Brady, Peter McGuirk and Kingston H. G. Mills; 11. Dendritic cells in the gut and their possible role in the pathogenesis of inflammatory bowel diseases Christopher Becker.