Salmonella enterica encompasses a diverse range of bacteria that cause a spectrum of diseases in many hosts. Advancements in prevention and treatment of S. enterica infections have at times been hampered by compartmentalization of research efforts and lack of multidisciplinary approaches. This book attempts to cover a diverse range of topics related to the biology of S. enterica infections, including epidemiological and clinical aspects, molecular pathogenesis, immunity to disease and vaccines. S. enterica infections are important zoonoses and therefore material on infections of animals and public health issues have also been considered. Each chapter can be read independently, but the full contents of the book will provide the reader with up-to-date knowledge on all the key aspects of salmonellosis in humans and animals. It will therefore be of interest to graduate students and researchers, as well as to clinicians, whose research focuses on this important pathogen.
Pietro Mastroeni is a Lecturer in the Department of Veterinary Medicine at the University of Cambridge, where he leads the Bacterial Immunology Team. Duncan Maskell is Professor of Microbiology and Head of the Department of Veterinary Medicine at the University of Cambridge.
1. Epidemiological and clinical aspects of human typhoid fever Christopher M. Parry; 2. Antibiotic resistance in Salmonella infections Fiona J. Cooke and John Wain; 3. Host-specificity of Salmonella infections in animal species Timothy S. Wallis; 4. Public health aspects of Salmonella enterica in food production Tom Humphrey; 5. The Salmonella genome: a global view Anne L. Bishop, Gordon Dougan and Stephen Baker; 6. Pathogenicity islands and virulence of Salmonella enterica Michael Hensel; 7. In vivo identification, expression and function of Salmonella virulence genes Helen Andrews-Polymenis, Caleb W. Dorsey, Manuela Raffatellu and Andreas J. Baumler; 8. Mechanisms of immunity to Salmonella infections Pietro Mastroeni; 9. Interactions of Salmonella enterica with phagocytic cells Bruce D. McCollister and Andres Vazquez-Torres; 10. Interactions between Salmonella and dendritic cells: what happens along the way? Cecilia Johansson, Malin Sundquist and Mary Jo Wick; 11. Immunity to Salmonella in domestic (food animal) species Paul Wigley, Paul Barrow and Bernardo Villarreal-Ramos; 12. Newer vaccines against typhoid fever and gastrointestinal Salmonelloses Richard A. Strugnell and Odilia L. C. Wijburg; 13. Salmonella enterica-based antigen delivery systems Jose A. Chabalgoity.