The volume contains recent advances in research on neurodegeneration and neuroinflammation. Particular interest was focused on molecular biological aspects of the mechanism of neuronal death in neurodegenerative disorders, particularly Parkinson's disease, Alzheimer's disease, spinocerebellar degeneration and multiple sclerosis. International opinion leaders and top class researchers reviewed the progress in the above subjects. Future aspects of neuroprotection in neurodegenerative disorders and neuroinflammatory disorders were also discussed.
Huntington disease: insights on the role of huntington cleavage.- PARKIN as a pathogenic gene for autosomal recessive juvenile parkinsonism.- Autosomal-dominantly inherited forms of Parkinson's disease.- Role of anti-apoptotic Bcl-2 protein in spinal muscular atrophy.- Subcellular localization of a-synuclein in primary neuronal cultures: effect of missense mutations.- Roles of Ab [beta] and carboxyl terminal peptide fragments of amyloid precursor protein in Alzheimer disease.- Iron chelating, antioxidant and cytoprotective properties of dopamine receptor agonist; apomorphine.- The motor circuit of the human basal ganglia reconsidered.- Involvement of endogenous N-methyl(R)salsolinol in Parkinson's disease: induction of apoptosis and protection by (-)deprenyl.- The myelin oligodendrocyte glycoprotein (MOG): a model for antibody-mediated demyelination in experimental autoimmune encephalomyelitis and multiple sclerosis.- Role of caspase-1 subfamily in cytotoxic cytokine-induced oligodendrocyte cell death.- Cytokines in Parkinson's disease.- Apoptosis as a general cell death pathway in neurodegenerative diseases.- Dentatorubral-pallidoluysian atrophy (DRPLA).- Gene therapy of Parkinson's diseae using Adeno-Associated Virus (AAV) vectors.- Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy.- Optic-spinal form of multiple sclerosis and immune-mediated myelopathy in Japan.
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Softcover reprint of the original 1st ed. 2000