Adverse Events and Oncotargeted Kinase Inhibitors

Adverse Events and Oncotargeted Kinase Inhibitors

By: Giuseppe Tridente (author)Hardback

Special OrderSpecial Order item not currently available. We'll try and order for you.

Description

Adverse Events and Oncotargeted Kinase Inhibitors gathers and evaluates data on adverse events associated with tyrosine kinase inhibitors (TKIs), a powerful anti-tumor drug class that has recently been introduced for human therapy. This book compiles a comprehensive safety profile of each TKI from experiences in official therapeutic indications, also exploring off-label exploratory investigations and postmarketing pharmaceutical surveillance databases. A brief history of each drug's development and submission is provided, along with a more detailed analysis of the mechanism(s) of action involved in therapeutic activity or related to the insurgence of specific adverse events. Early chapters focus on general characteristics of TKIs, typology, and classification of adverse events, while the final chapters analyze TKIs as AE inducers and classes of AEs by system or organ involvement. This comprehensive resource compiles and critically reviews all of the relevant safety data for this class of drugs, with the goal of improving the understanding of pathogenesis and facilitating the prevention, monitoring, and management of these adverse events.

About Author

Professor Emeritus of Immunology and PathologySchool of Medicine and SurgeryCoordinator of the Teachers' Committee for the Master in Translational BiomedicineUniversita degli Studi di Verona, Italy

Contents

Part I: General Aspects 1. Introduction 2. Protein and Lipid Kinases 3. Kinase Inhibitors 4. Adverse Events Part II: Oncotargeted Kinase Inhibitors 5. Imatinib 6. Gefitinib 7. Erlotinib 8. Sorafenib 9. Sunitinib 10. Dasatinib 11. Lapatinib 12. Nilotinib 13. Pazopanib 14. Vandetanib 15. Vemurafenib 16. Crizotinib 17. Ruxolitinib 18. Axitinib 19. Bosutinib 20. Regorafenib 21. Cabozantinib 22. Ponatinib 23. Dabrafenib 24. Trametinib 25. Adatinib 26. Idelalisib 27. Ibrutinib Part III: Overview 28. Kinase Inhibitors as Adverse Event Inducers 29. Kinase Inhibitors as Drug Class Events 30. Conclusion and Perspectives

Product Details

  • ISBN13: 9780128094006
  • Format: Hardback
  • Number Of Pages: 736
  • ID: 9780128094006
  • weight: 2220
  • ISBN10: 0128094001

Delivery Information

  • Saver Delivery: Yes
  • 1st Class Delivery: Yes
  • Courier Delivery: Yes
  • Store Delivery: Yes

Prices are for internet purchases only. Prices and availability in WHSmith Stores may vary significantly

Close