With the ever-increasing rise in life expectancy, there is an urgent need to improve our understanding of the relationship between ageing and the pathogenesis of age-related diseases in order to identify more effective means of prevention, amelioration and management of such diseases. In addition, there is a need to reduce the social and economic impact of the ageing population. Age-related morbidity and mortality vary dramatically among individuals; this book focusses on individual differences in susceptibility to age-related disorders. It contains contributions from leading experts in the field on topics such as: age-related pathology in the brain, age-related processes in stem cells, and age-related effects on the immune system and in bone, muscle and cardiovascular tissue. For all those with an interest in the biology of ageing, this is compulsory reading.
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Introduction (T. Kirkwood). The Priority of Basic Research on Ageing Vulnerability in a Comprehensive Research Agenda on Ageing for the 21st Century (G. Andrews). Do Alterations in Glutathione and Iron Levels Contribute to Pathology Associated with Parkinson's Disease? (J. Andersen). Specific Metal-Catalysed Protein Oxidation Reactions in Chronic Degenerative Disorders of Ageing: Focus on Alzheimer's Disease and Age-Related Cataracts (A. Bush & L. Goldstein). General Discussion I: The Role of Glial Cells in the Ageing Brain. Multiple Substrates of Late-Onset Dementia: Implications for Brain Protection (R. Kalaria, et al.). Ageing of Murine Small Intestinal Stem Cells (C. Potten, et al.). Haematopoietic Stem Cell Ageing (A. Globerson). General Discussion II. Identification of Genes Involved in Cell Senescence and Immortalization: Potential Implications for Tissue Ageing (J. Leung & O. Pereira-Smith). Ageing and Cancer: The Telomere and Telomerase Connection (J. Shay & W. Wright). Ageing and the Immune System (R. Effros). General Discussion III. Mechanisms of Age-Related Bone Loss (L. Mosekilde). The Old Heart: Operating on the Edge (E. Lakatta, et al.). Pharmaceutical Intervention of Advanced Glycation Endproducts (A. Cerami & P. Ulrich). General Discussion IV. The Anti-Ageing Action of Dietary Restriction (H. Van Remmen, et al.). Mitochondrial DNA Mutations in Disease and Ageing (D. Cottrell). A Mitochondrial Paradigm for Degenerative Diseases and Ageing (D. Wallace). Final Discussion. Index of Contributors. Subject Index.