Aluminium is the most abundant metal ion in the biosphere and we are continuously exposed to it in our everyday life through food, beverages, pharmaceutical products, etc. This book is a current and comprehensive review of the biochemistry, metabolism and toxicity of aluminium undertaken by an international group of authors, many of whom are outstanding authorities in their respective fields. In contrast with previous books on this topic, much of the subject matter is unique, in that it is primarily directed at aluminium nutrition and toxicity in infants and children. This book covers many aspects of aluminium toxicity in infants including for instance the embryo-fetal as well as the neurodevelopmental effects of this element, contamination of pharmaceutical products, and individual sensitivity through vaccines using aluminium as an adjuvant.This book will be especially useful to paediatricians, paediatric nephrologists & neurologists, nutritionists, toxicologists, biochemical toxicologists and postgraduate students.
Part 1 Chemistry, biochemistry and physiology: the importance of aluminium chemistry in biological systems, R.B. Martin; aluminium-26 as a biological tracer using accelerator mass spectrometry, R. Flack and D. Elmore; aluminium toxicity depends on the metal speciation, P.F. Zatta and P. Zambenedetti; aluminium metabolism, A.C. Alfrey; aluminium and iron relationship - pathophysiological and clinical overview, J.B. Cannata Andia. Part 2 Paediatrics: aluminium in infancy, K. Simmer; aluminium toxicity in infants, M. McGraw; aluminium-related bone disease in children with renal failure, B.D. Kuizon and I.B. Salusky; aluminium and antiacids in infants, J.W.L. Puntis; development and aluminium experimental toxicity, J.L. Domingo. Part 3 Paediatric pharmacology: aluminium content of parental nutrition products, G.L. Klein; aluminium content in the intravenous treatment in infants, A. Moreno et al; aluminium in human albumin solutions, B. Gammelgaard and O. Jons; reduction of aluminium levels in albumin products, Y. Uemura et al; toxicity of aluminium compounds as an adjuvant for vaccines, N. Goto; a public health analysis of dietary aluminium, S. Humphreys and P.M. Bolger.