Section 1: Attitudes and Policies. Editor's introduction. Introduction. Asylums exclusively for the incurable insane (1844). The moral treatment of insanity (1847). Gheel (1851). A sketch of the history, buildings, and organization of the Pennsylvania Hospital for the Insane (1845). Address before the fiftieth annual meeting of the American Medico-Psychological Association, held in Philadelphia, May 16, 1894. Some remarks on the address delivered to the American Medico-Psychological Association, by S. Weir Mitchell, M.D., May 16, 1894. A short sketch of the problems of psychiatry (1897). The attitude of neurologists, psychiatrists, and psychologists towards psychoanalysis (1939). Some trends of psychiatry (1944). Benjamin Rush and American history (1944). The role of psychiatry in the world today (1947). Current trends in German psychiatry (1949). Reminiscences: 1938 and Since (1990). Section II: Clinical Description. Introduction. Definition of insanity-nature of the disease (1844). Katatonia: a clinical form of insanity (1877). The curability of insanity: a statistical study (1885). Personality changes and upheavals arising out of the sense of personal failure (1926). The onset of schizophrenia (1927). In memoriam: Emil Kraepelin (1927). The acute schizoaffective psychoses (1933). Symptomatology and management of acute grief (1944). Irrelevant and metaphorical language in early infantile autism (1946). Section III: Research: Methods, Mechanisms, and Causes. Introduction. The importance of a correct physiology of the brain, as applied to the elucidation of medico-legal questions; and the necessity of greater accuracy and minuteness in reporting post mortem examinations (1845). Statistics of insanity (1849). A review of the signs of degeneration and of methods of registration (1896). Influenza and schizophrenia (1926). The genetic theory of schizophrenia (1946). The concepts of meaning and cause in psychodynamics (1947). Cerebral blood flow and metabolism in schizophrenia (1948). Research and its support under the national mental health act (1949). Section IV: Developments in Somatic Treatment. Introduction. Observations on the medical treatment of insanity (1850). The history of the malarial treatment of general paralysis (1935). Prefrontal leucotomy in the treatment of mental disorders (1937). The methodical use of hypoglycemia in the treatment of psychoses (1937). Curare: a preventive of traumatic complications in convulsive shock therapy (1941). The society of Alcoholics Anonymous (1949). The use of antabase (tetraethylthiuramdisulphide) in chronic alcoholics (1950). Chlorpromazine treatment of mental disorders (1955). Clinical findings in the use of tofranil in depressive and other psychiatric states (1959). The use of lithium in the affective psychoses (1966).