Aminophosphinic and Aminophosphonic Acids: Chemistry and Biological Activity

Aminophosphinic and Aminophosphonic Acids: Chemistry and Biological Activity

By: H.R. Hudson (author), Valery P. Kukhar (author)Hardback

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Description

This text presents all aspects of the chemistry and biological activity of aminophosphinic and aminophosphonic acids and their derivatives including esters and peptides, with emphasis on contemporary research in agrochemical and biomedical applications. The book includes structural and spectroscopic data, covers research in biological activity with special reference to protease inhibition and possible clinical applications, and explores the use of aminophosphinic and aminophosphonic derivatives as agrochemicals and their future potential.

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Contents

Naturally Occurring Aminophosphonic and Aminophosphinic Acids (P. Mastalerz & P. Kafarski); Synthesis of -Aminoalkanephosphinic Acids (P. Kafarski & J. Zo ); Synthesis of Aminoalkanephosphonic and Aminoalkanephosphinic Acids with the Amino Substituent in Other than the -Position (V. Kukhar); -Amino Acid Analogues Bearing Side-Chain C-P Linkages (S. Lall and R. Engel); Asymmetric Synthesis of Aminophosphonic and Aminophosphinic Acids (V. Kukhar); Synthesis of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejczak); Column Chromatography of Aminophosphonic Acids and Phosphonopeptides (S. Galushko); Physical Properties and NMR-Spectroscopic Characterization of Aminophosphonates and Aminophosphinates (G. Hdgele); Structure and Stability Constants of Metal Complexes in Solution (T. Kiss & I. Lazar); X-Ray Crystallographic Studies (N. Choi & M. McPartlin); Mass Spectrometry and Gas Chromatography-Mass Spectrometry of Aminoalkanephosphonic Acids (Z. Kudzin & M. Sochaki); The Biological Activity of Phosphono- and Phosphinopeptides (P. Kafarski & B. Lejezak); Aminophosphonic and Aminophosphinic Acids and their Derivatives as Agrochemicals (H. Hudson); Neuroactive Aminophosphonic and Aminophosphinic Acid Derivatives (D. Jane); Aminophosphonic and Aminophosphinic Acid Derivatives in the Design of Transition State Analogue Inhibitors: Biomedical Opportunities and Limitations (J. Oleksyszyn); Aminophosphonic and Aminophosphinic Acids in the Design and Synthesis of HIV Protease Inhibitors (A. Peyman); Aminophosphonic Acid Derivatives as Antithrombotic Agents (D. Green, et al.); Aminophosphonic and Aminophosphinic Acid Derivatives as Inhibitors of Human Collagenase (R. Markwell); Index.

Product Details

  • publication date: 30/03/2000
  • ISBN13: 9780471891499
  • Format: Hardback
  • Number Of Pages: 660
  • ID: 9780471891499
  • weight: 1062
  • ISBN10: 0471891495

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