While considerable advances have been made in management of psoriasis in the last ten years, there is still no absolute cure, and no simple, safe, and invariably effective treatment. Therefore, the need for an up-to-date, authoritative, visually stunning, practical aid to diagnosis continues to be paramount for effective treatment of this disease.
Written by Lionel Fry, one of the world's most distinguished dermatologists, this completely revised second edition is a full update of the internationally acclaimed first edition of An Atlas of Psoriasis. Copiously illustrated in color, including new high quality visual imagery only recently available, the atlas highlights new treatment options such as light therapy and topical, systemic, and immunomodulatory drugs. Providing an authoritative review of psoriasis, the book is an essential reference for dermatologists, dermatopathologists, internists, and family physicians.
Introduction EPIDEMIOLOGY AND HISTOLOGY PROGNOSIS GENETICS Family Studies Census Studies Twin Studies Human Leukocyte Antigens Chromosome Loci and Possible Genes ETIOLOGY Environmental Triggers Physical Trauma Infections Stress Drugs Hypocalcemia Alcohol Climate PATHOGENESIS Immunopathology Antigen-Presenting Cells Cytokines Nature of the Antigen Streptococcal Exotoxins Cellular Streptococcal Proteins Evidence for M Protein Being the Antigen in Psoriasis Evidence for Other Cell Wall and Membrane Peptides Being the Antigen in Psoriasis Are the Effector T Cells in Psoriasis CD4 or CD8? How Do the T Cells Enter the Skin? The Innate Immune System CLINICAL FEATURES Age of Onset Sex Predilection Morphology SITES AND CLINICAL PATTERNS Plaque Psoriasis Guttate Psoriasis Chronic Plaque Combined with Guttate Psoriasis Koebner Phenomenon Erythrodermic Psoriasis Pustular Psoriasis Acral Psoriasis Seborrheic Psoriasis Childhood Psoriasis Diaper 'Psoriasis' Linear Psoriasis Psoriasis at Specific Sites DIFFERENTIAL DIAGNOSIS Chronic Plaque Psoriasis Guttate Psoriasis Erythrodermic Psoriasis Generalized Pustular Psoriasis Localized Pustular Psoriasis Acral Psoriasis Seborrheic Psoriasis Childhood Psoriasis Scalp Psoriasis Psoriasis of the Palms and Soles Flexural Psoriasis Nails Linear Psoriasis PSORIATIC ARTHROPATHY Epidemiology Genetics Clinical Features in Peripheral Arthropathy Spinal Arthritis Relationship Between Skin Lesions and Arthropathy Relationship Between Nail Involvement and Arthropathy Extra-Articular Features Treatment Prognosis TREATMENT Topical Drugs Oral therapy Combined Treatments Biologicals Future Treatments References Index