An Introduction to Drug Synthesis explores the central role played by organic synthesis in the process of drug design and development. Written by an experienced and talented author to complement his existing An Introduction to Medicinal Chemistry, the book illustrates how organic synthesis makes important contributions throughout the drug design and discovery process - from the generation of novel drug structures to the improved efficiency of large scale synthesis. Avoiding excessively detailed descriptions of the underlying synthetic pathways, the book focuses on how synthesis can be used in a strategic way - how and why different synthetic approaches are adopted, and the pros and cons of each. With examples used extensively to illustrate the concepts presented, An Introduction to Drug Synthesis> is the ideal resource for any pharmaceutical or medicinal chemistry student who needs a thorough understanding of how the concepts of organic synthesis are applied to the development of therapeutic drugs.
Online Resource Centre An Introduction to Drug Synthesis is supported by an Online Resource Centre featuring: For registered adopters: - Figures from the book in electronic format; For students: - A suite of multiple-choice questions to support the learning process; - Additional case studies - More detailed descriptions of key synthetic reactions, as a source of further reference.
Graham Patrick is a lecturer in Organic Chemistry and Medicinal Chemistry at the University of the West of Scotland, Glasgow. He is the author of four other undergraduate textbooks covering medicinal chemistry and organic chemistry, including Introduction to Medicinal Chemistry, which is now in its fifth edition.
PART A: Concepts ; 1. The drug discovery process ; 2. Drug synthesis ; 3. Retrosynthesis ; 4. Cyclic systems in drug synthesis ; 5. The synthesis of chiral drugs ; 6. Combinatorial and parallel synthesis ; PART B: Applications of drug synthesis in the drug development process ; 7. Synthesis of lead compounds ; 8. Analogue synthesis in drug design ; 9. Synthesis of natural products and their analogues ; 10. Chemical and process development ; 11. Synthesis of isotopically labelled compounds ; PART C: Design and synthesis of selected antibacterial agents ; 12. Design and synthesis of tetracyclines ; 13. Erythromycin and macrolide antibacterial agents ; 14. Quinolones and fluoroquinolones
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- ID: 9780198708438
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