Epilepsy is fairly unique among the various neurological disorders as it provides the neuroscientist with almost boundless opportunities to examine basic neurobiological mechanisms. Not surprisingly, advances in epilepsy research are closely tied to dev- opment of innovative neurobiological methodologies. In many cases the practical application of these innovations - especially in the context of a neurological disorder with anatomical, molecular, electrophysiological, and behavioral components such as epilepsy - can be found in the development of new animal models. In turn, our understanding of the pathogenesis of epilepsy (and new therapy development) greatly benefits from these models. Taking advantage of transgenic and homologous rec- binationtechniques,laboratorieshave recentlymovedbeyondthestandardconvulsant or stimulation models in rat to develop novel mouse models of epilepsy. This forward thinking approach has recently been applied to genetically tractable "simple" species such as Drosophila melanogaster (fruit flies), Caenorhabditis elegans (worms), Xenopus laevis (tadpoles), and Danio rerio (zebrafish).
With contributions from prominent investigators in this field, this book provides a reviewoftheseemerginganimalmodelsofepilepsy. Priortextbooksdevotedtomodels of seizure and epilepsy almost exclusively categorized rat models with little attention paid to these more innovative approaches. Here we attempt to diverge from the conventionalepilepsyliteratureandfocusonanimalmodelsthatattempttoincorporate the latest technological advancements in neurobiology. While some of these models andapproaches are,admittedly, at veryearly stages ofdevelopment andmay ultimately fall short of widespread utilization, it is through the consideration and presentation of these models that the authors' hope to advance and challenge the field of epilepsy research.
1. The Nematode, C. elegans, as an Emerging Model for Investigating Epilepsy Cody J. Locke, Kim A. Caldwell, and Guy A. Caldwell 2. The Genetics and Molecular Biology of Seizure Susceptibility in Drosophila Juan Song and Mark A. Tanouye 3. The Albino Xenopus laevis Tadpole as a Novel Model of Developmental Seizures D. Sesath Hewapathirane and Kurt Haas 4. Zebrafish as a Simple Vertebrate Organism for Epilepsy Research Scott C. Baraban 5. Modeling Tuberous Sclerosis Complex: Brain Development and Hyperexcitability Kevin C. Ess 6. BK Potassium Channels Mutations Affecting Neuronal Function and Epilepsy David Petrik, Qing H. Chen, and Robert Brenner 7. Mouse Models of Benign Familial Neonatal Convulsions (BFNC): Mutations in KCNQ (Kv7) Genes Nanda A. Singh, James F. Otto, Mark F. Leppert, H. Steve White, and Karen S. Wilcox 8. Interneuron Loss as a Cause of Seizures: Lessons from Interneuron-Deficient Mice Dorothy Jones-Davis, Maria-Elisa Calcagnotto, and Joy Y. Sebe 9. Imaging Seizure Propagation In Vitro Andrew J. Trevelyan and Rafael Yuste 10. Complexity Untangled: Large-Scale Realistic Computational Models in Epilepsy Robert J. Morgan and Ivan Soltesz 11. Organotypic Hippocampal Slice Cultures as a Model of Limbic Epileptogenesis Suzanne B. Bausch 12. Seizure Analysis and Detection In Vivo Javier Echauz, Stephen Wong, and Brian Litt 13. Viral Vector Gene Therapy for Epilepsy Stacey B. Foti, Shelley J. Russek, Amy R. Brooks-Kayal, and Thomas J. McCown 14. Neural Stem Cells in Experimental Mesial Temporal Lobe Epilepsy Michelle M. Kron and Jack M. Parent