Authored by two leading investigators, this book presents a thorough and authoritative overview of this multifaceted field of science. Pathogenic bacteria have been evolving and spreading resistance to diverse classes of antibiotics. As a result, we risk losing our ability to control and treat infectious diseases. Understanding antibiotic resistance, therefore, is becoming increasingly essential for a broad audience of healthcare professionals, biomedical and public health researchers, students, and policymakers. The authors answer questions such as: What is resistance? How does it emerge? How do common human activities contribute to resistance? What can we do about it? How can we strengthen our "first lines of defense" against resistance? Are there better ways to discover new antibiotics? What unique issues are associated with MRSA and viral influenza? In addition to defining and evaluating one of the most important emerging threats to public health, the authors explain what can be done to minimize risks to public health, and to preserve and extend the effectiveness of existing and new antibiotics.
Karl Drlica, Ph.D. is a Principal Investigator at the Public Health Research Institute and Professor of Microbiology & Molecular Genetics at the UMDNJ-New Jersey Medical School in Newark. His laboratory focuses on fluoroquinolone action and resistance with Mycobacteriun tuberculosis and other bacteria, including approaches for slowing the enrichment and amplification of resistant bacterial subpopulations. David S. Perlin, Ph.D. is Executive Director of the Public Health Research Institute and UMDNJ Regional Biocontainment Laboratory, as well as Professor of Microbiology & Molecular Genetics at the New Jersey Medical School in Newark. He is also a Fellow of the New York Academy of Sciences. Dr. Perlin's laboratory explores mechanisms of antifungal drug-resistance, rapid detection of drug resistant bloodstream pathogens in high-risk patients, and the application of small-animal models for the study of respiratory pathogens.
Preface xv Chapter 1 Introduction to the Resistance Problem 1 Chapter 2 Working with Pathogens 17 Chapter 3 A Survey of Antibiotics 31 Chapter 4 Dosing to Cure 55 Chapter 5 Emergence of Resistance 73 Chapter 6 Movement of Resistance Genes Among Pathogens 91 Chapter 7 Transmission of Resistant Disease 105 Chapter 8 Surveillance 125 Chapter 9 Making New Antibiotics 139 Chapter 10 Restricting Antibiotic Use and Optimizing Dosing 149 Chapter 11 Influenza and Antibiotic Resistance 167 Chapter 12 Avoiding Resistant Pathogens 177 Afterword A Course of Action 203 Appendix A Molecules of Life 207 Appendix B Microbial Life Forms 221 Glossary 227 Literature Cited 233 Index 251
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