Antimicrobial Drug Discovery: Emerging Strategies (Advances in Molecular and Cellular Microbiology No. 22)
By: Eleftherios Mylonakis (editor), George Tegos (editor)Hardback
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Resistance is on the rise among a variety of human pathogenic microorganisms associated with common and potentially life-threatening infections, including penicillin-resistant Streptococcus pneumonia and Methicillin-resistant Staphylococcus aureus (MRSA). There is increasing demand to approach the threat of multidrug resistance incorporating novel multidisciplinary methodologies and technological platforms. This book documents the latest research, covering current and promising activities in four key areas: computational chemistry and chemoinformatics, High Throughput Screening (HTS), non-vertebrate model hosts and light and nano-based technologies. It is essential reading for researchers and students in microbiology, biotechnology, pharmacology, chemistry and biology as well as medical professionals.
1. Emerging Antimicrobial Drug-discovery Strategies: an Evolving Necessity; 2. The Antibiotic Crisis; 3. Structure, Genetic Regulation, Physiology and Function of the AcrAB-TolC Efflux Pump of Escherichia coli and Salmonella; 4. Small-molecule Efflux Pump Inhibitors from Natural Products as a Potential Source of Antimicrobial Agents; 5. Fungal Efflux-mediated Resistance: from Targets to Inhibitors; 6. Vacuolar ATPase: a Model Proton Pump for Antifungal Drug Discovery; 7. Drug Tolerance, Persister Cells and Drug Discovery; 8. Inhibition of Quorum Sensing as a Novel Antimicrobial Strategy; 9. Filamentous Temperature-sensitive Mutant Z (FtsZ) Protein as an Antibacterial Target; 10. Lysostaphin: a Silver Bullet for Staph; 11. Strategies to Identify Modified Ribosomally Synthesized Antimicrobials; 12. Quantitative Structure-Activity Relationship-based Discovery of Antimicrobial Peptides Active Against Multidrug-resistant Bacteria; 13. Acetyl-CoA Carboxylase as a Target for Antibacterial Development; 14. Underexploited Targets in Lipopolysaccharide Biogenesis for the Design of Antibacterials; 15. Predicting and Dissecting High-order Molecular Complexity by Information-driven Biomolecular Docking; 16. Antifungals and Antifungal Drug Discovery; 17. Pathosystematic Studies and the Rational Design of Antifungal Interventions; 18. In Vivo High-throughput Antimicrobial Discovery Screens Utilizing Caenorhabditis elegans as an Alternative Host; 19. Drosophila melanogaster as a Versatile Model for the Discovery of Drugs Effective against Human Microbe-induced Infection and Pathology; 20. Antimicrobial Photosensitizers: Harnessing the Power of Light to Treat Infections; 21. Nanoparticle Platforms for Antimicrobial Therapy; 22. Antimicrobial Activity of Carbon Nanotubes.
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- ID: 9781845939434
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