Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies (Advances in Molecular and Cellular Microbiology No.18 18th)
By: G. Wang (editor)Hardback
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Antimicrobial Peptides (AMPs) are an organism's built-in defence molecules that have attracted extensive research attention worldwide. Harnessing and creating them synthetically has the potential to help overcome increasing antibiotic resistance in many pathogens. In addition to covering the current advances in AMP research, this volume examines new technologies such as bioinformatics, combinatorial libraries, high-throughput screening, peptidomimetics, biophysics, and structural biology. This volume also describes new methods and strategies for AMP prediction, design, and applications that overcome obstacles in developing them into therapeutic agents.
Part I: Natural Antimicrobial Peptides: Host Expression, Identification, and Characterization; 1. AMPs in Bacteria; 2. AMPs in Plants; 3. AMPs in Amphibians; Part II: Man-made AMPs: Peptide Discovery, Design and Peptidomimetics; 4. Bioinformatics Discovery of Potential AMPs and Database-aided Peptide Design; 5. Library-based Peptide Identification; 6. Chemical Synthesis of Peptide Mimetics; Part III: Biophysics, Structural Biology, and Mechanism of Action of AMPs; 7. Biophysical Analysis of Membrane-targeting AMPs; 8. Identification of Non-membrane Targets of AMPs; 9. Structural Biology of AMPs: Insight into their Mode of Action and Structure-based Peptide Engineering; Part IV: Novel Therapeutic Strategies to Bolster Host Defense; 10. Methods to Liberate Human LL-37 in the Complex State; 11. Gene Therapy and Enhancement of AMP Expression by Using Natural Ligands; 12. Modulation of Human Immune Response by Non-AMPs as a Novel Approach to Battle Infectious Diseases.
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- ID: 9781845936570
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