This book represents a cutting edge summary of one of the most important fields in innate immunity. Antimicrobial peptides rapidly and directly inhibit infection by microbes and are of enormous importance in the body's natural defence against disease. In addition the role of antimicrobial peptides in the development of therapeutic agents for the prevention and treatment of disease is becoming increasingly important.
Written by the leaders in the field this book provides an understanding of the implications of antimicrobial peptides in human disease. The volume is divided into sections containing reviews of specific families of antimicrobials, select organ systems that have demonstrated a relevance for antimicrobial peptides and, in addition, a more global discussion of these peptides and organs from distinct perspectives. Alternatively, each chapter can stand on its own, providing the reader with the ability to dive right into the subject of most interest.
Topics covered include cathelicidins, alpha and beta defensins, granulysin, hepcidin, the role of antimicrobial peptides in blood, gut, skin, lung and in the oral environment. A recurring theme is the possibility of creating therapeutics that induce the expression of endogenous antimicrobial peptides for the prevention or treatment of disease.
Introduction. General Concepts of Antimicrobial Peptides, Past and Future. Section 1. Select Diverse Peptides with Antimicrobial Action in Humans. 1. The Role of Cathelicidins in the Innate Host Defences of Mammals. 2. The Role of Alpha and Beta Defensins in Human Defense. 3. Granulysin. 4. Hepcidin. Section 2 Tissues and their use of Antimicrobial Peptides. 5. Antimicrobial Peptides in Human Blood. 6. The Role of Paneth Cell a-Defensins in Enteric Innate Immunity. 7. Lung. 8. Antimicrobial Peptides in the Oral Environment: Expression and Function in Health and Disease. 9. Natural Antimicrobial Peptides: A Barrier against Human Skin Infection. Section 3 Clinical Concepts. 10. Antimicrobial Peptide Resistance in Human Bacterial Pathogens. 11. A Pediatric Perspective on Antimicrobial Proteins and Peptides: Expression, Function, and Clinical Relevance. 12. Therapeutic Applications of Innate Immunity Peptides.