Antipsychotic Trials in Schizophrenia: The CATIE Project

Antipsychotic Trials in Schizophrenia: The CATIE Project

By: T. Scott Stroup (editor), Jeffrey A. Lieberman (editor)Hardback

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Antipsychotic medications are a key treatment for schizophrenia and sales of antipsychotic drugs approach $20 billion per year, with fierce marketing between the makers of the drugs. The U.S. National Institute of Mental Health sponsored the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project to provide independent information about the comparative effectiveness of medications. CATIE was the largest, longest and most comprehensive study of schizophrenia to date. Conducted under rigorous double-blind conditions, Antipsychotic Trials in Schizophrenia presents the definitive archival results of this landmark study. The core of the book consists of chapters focused on specific outcomes that set the CATIE findings in a wider context. Also included are chapters on the design, statistical analyses and implications for researchers, clinicians and policy makers. Psychiatrists, psychiatric researchers, mental health policy makers and those working in pharmaceutical companies will all find this to be essential reading.

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About Author

Scott Stroup is Professor of Psychiatry at the University of North Carolina, Chapel Hill, USA. He was co-Principal Investigator of the CATIE Schizophrenia Study. Jeffrey A. Lieberman is Chairman, Department of Psychiatry, College of Physicians and Surgeons, Columbia University, Director, New York State Psychiatric Institute and Director, Lieber Center for Schizophrenia Research Psychiatrist-in-Chief at New York Presbyterian Hospital and Columbia University Medical Center, New York, USA.


List of contributors; Acknowledgements; Introduction; 1. Study design and protocol development process T. Scott Stroup, Joseph P. McEvoy and Jeffrey A. Lieberman; 2. Statistical considerations Sonia M. Davis, Gary G. Koch, Robert A. Rosenheck and Vicki G. Davis; 3. Effectiveness and efficacy: staying on treatment and symptom reduction Joseph P. McEvoy, T. Scott Stroup and Jeffrey A. Lieberman; 4. Cost-effectiveness and cost-benefit analysis Robert A. Rosenheck and Douglas L. Leslie; 5. Psychosocial functioning in patients with chronic schizophrenia: findings from the NIMH CATIE study Marvin S. Swartz; 6. Neurocognition Richard S. E. Keefe; 7. Vocational outcomes Sandra G. Resnick and Robert A. Rosenheck; 8. Family outcomes Deborah A. Perlick, Richard Kaczynski and Robert A. Rosenheck; 9. Extrapyramidal side effects Stanley N. Caroff, Del D. Miller and Robert A. Rosenheck; 10. Metabolic side effects and risk of cardiovascular disease Jonathan M. Meyer, Donald C. Goff and Joseph P. McEvoy; 11. Substance use in persons with schizophrenia: incidence, baseline correlates, and effects on outcome Fred Reimherr, Marvin S. Swartz and John L. Olsen; 12. Violence in schizophrenia: prevalence, correlates, and treatment effectiveness Jeffrey Swanson and Richard Van Dorn; 13. Genetic investigations in the CATIE sample James J. Crowley and Patrick F. Sullivan; 14. Human subjects considerations T. Scott Stroup and Paul Appelbaum; 15. Population pharmacokinetics of antipsychotics Kristin L. Bigos, Robert R. Bies, Stephen R. Marder and Bruce G. Pollock; 16. Implications for research design and study implementation T. Scott Stroup and Jeffrey A. Lieberman; 17. Conclusion and implications for practice and policy Robert A. Rosenheck, T. Scott Stroup and Jeffrey A. Lieberman.

Product Details

  • publication date: 01/04/2010
  • ISBN13: 9780521895330
  • Format: Hardback
  • Number Of Pages: 330
  • ID: 9780521895330
  • weight: 700
  • ISBN10: 0521895332

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