Antisense Therapeutics (Methods in Molecular Biology)
By: Sudhir Agrawal (editor)Hardback
2 - 4 weeks availability
Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book's high profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.
History of Antisense Oligonucleotides. Pharmacology of Antisense Therapeutic Agents: Cancer and Inflammation. Antisense Efficacy: Site- Restricted In Vivo and Ex Vivo Models. Antisense Blockade of Expression: SNAP-25 In Vitro and In Vivo. Antisense Tumor Therapy: Activated C-Ha-ras Oncogene in the Mouse. Antisense Inhibition of Protein Synthesis and Function: Rabbit Retinal Protein. c-Myb in Smooth Muscle Cells. Antisense Therapy of Hepatitis B Virus Infection: In Vivo Analyses in the Duck Hepatitis B Virus Model. Antisense-Mediated Inhibition of Protein Synthesis: Rational Drug Design Pharmacokinetics Intracerebral Application and Organ Uptake of Phosphorothioate Oligodeoxynucleotides. Antisense rel A in Cancer. Continuous Infusion of Antisense Phosphorothioate Therapeutics. Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo: The Antisense Effects Outlast Antisense Survival. Antisense Therapeutics in the Central Nervous System: The Induction of c-fos. Comparative Pharmacokinetics of Antisense Oligonucleotides. Index.
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- ID: 9780896033054
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