Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development

Applications of Vibrational Spectroscopy in Pharmaceutical Research and Development

By: John M. Chalmers (editor), Don E. Pivonka (editor), Peter Griffiths (editor)Hardback

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Description

Although vibrational spectroscopy is a critical technology within the pharmaceutical industry, currently the literature regarding its applications in the field is fragmented. At present there is no single volume that brings together the diverse aspects of vibrational spectroscopy at a level that will provide value to the dedicated spectroscopist as well as to the synthetic, development and medicinal based chemists, alike. This volume aims to present key themes, established and emerging, within current research as well as presenting detailed contributions on the instrumentation, methodology, data treatment, and applications associated within this area of research. It will provide a consolidated "road map" to the practice of this science within the industry.

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Contents

Part One: Introduction Introduction to Vibrational Spectroscopy Peter R. Griffiths Part Two: Drug Discovery Sampling Techniques and Fiber-Optic Probes John M. Chalmers and Peter R. Griffiths Vibrational Spectroscopy in the Discovery Phase Component of Pharmaceutical Research Don E. Pivonka Applications of Vibrational Spectroscopy to Combinatorial Chemistry Don E. Pivonka Vibrational Spectroscopic Analysis for the Determination of Structure-Activity Relationships (SARs) in Molecular Binding Don E. Pivonka and Isao Noda Applications of Vibrational Optical Activity in the Pharmaceutical Industry Laurence A. Nafie and Rina K. Dukor Characterization and Optimization of Chemical Synthesis Using Real-Time Vibrational Spectroscopy Fadi Homsi, Paul Barrett, Jian Wang and Roel Ferwerda Part Three: Drug Development Infrared and Raman Spectroscopy for Process Development George Zhou, Robert Guenard and Zhihong Ge The Analysis of Pharmaceutical Substances and Formulated Products by Vibrational Spectroscopy Don Clark and Alexander Pysik Raman Analysis of Pharmaceuticals David E. Bugay, Jan-Olav Henck, Michael L. Longmire and Fiona C. Thorley Vibrational Spectroscopy of Solid-State Forms - Introduction, Principles and Overview Terry L. Threlfall and John M. Chalmers Vibrational Spectroscopy of Solid-State Forms - Applications and Examples David H. Igo and Pingyun Chen Pharmaceutical Applications of Chemical Mapping and Imaging Don Clark, Mark Henson, Fred LaPlant, Slobodan Sasic and Lin Zhang Terahertz Spectroscopy for Pharmaceutical Applications Mike Claybourn, Husheng Yang, Lubomir Gradinarsky, Jonas Johansson and Staffan Folestad Part Four: Conclusions History, Trends and Prognostications Peter R. Griffiths, John M. Chalmers and Don E. Pivonka

Product Details

  • publication date: 23/03/2007
  • ISBN13: 9780470870877
  • Format: Hardback
  • Number Of Pages: 384
  • ID: 9780470870877
  • weight: 1108
  • ISBN10: 0470870877

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