Aromatase Inhibitors (Milestones in Drug Therapy)

Aromatase Inhibitors (Milestones in Drug Therapy)

By: B. J. A. Furr (editor)Hardback

2 - 4 weeks availability

£98.50 With FREE Saver Delivery


Many breast tumours are dependent upon oestrogen for their development and continued growth. Over the last 25 years, hormone therapy has progressed from the irreversible destruction of endocrine glands to the use of drugs that reversibly suppress oestrogen synthesis or action. The inhibition of oestrogen synthesis is most readily achieved by inhibiting the final step in the pathway of oestrogen biosynthesis, the reaction which transforms androgens into oestrogens by creating an aromatic ring in the steroid molecule (hence the enzyme's trivial name, aromatase). Whereas, the first aromatase inhibitors to be used therapeutically could be shown to produce drug-induced inhibition of the enzyme and therapeutic benefits in patients with breast cancer, they were not particularly potent and lacked specificity. However, second-generation drugs were developed and most recently third-generation inhibitors have evolved which possess remarkable specificity and potency. Initial results from clinical trials suggest that these agents will become the cornerstones of future endocrine therapy.

Create a review


Background and development of aromatase inhibitors.- Aromatase inhibitors and models for breast cancer.- Clinical pharmacology of aromatase inhibitors.- Clinical studies with exemestane.- Clinical studies with letrozole.- Clinical studies with anastrozole.- The third-generation aromatase inhibitors: a clinical overview.- Lessons from the ArKO mouse.- Possible additional therapeutic uses of aromatase inhibitors

Product Details

  • publication date: 31/05/2005
  • ISBN13: 9783764371999
  • Format: Hardback
  • Number Of Pages: 191
  • ID: 9783764371999
  • ISBN10: 3764371994

Delivery Information

  • Saver Delivery: Yes
  • 1st Class Delivery: Yes
  • Courier Delivery: Yes
  • Store Delivery: Yes

Prices are for internet purchases only. Prices and availability in WHSmith Stores may vary significantly