This book covers the latest developments in asymmetric domino reactions, focussing on those published in the last 6 years. These fascinating reactions have rapidly become one of the most current fields in organic chemistry, since they allow reaching easily high molecular complexity in an economically favourable way with advantages of savings in solvent, time, energy, and costs. Unsurprisingly, the high levels of efficiency and enantioselectivity generally reached in these reactions have been exploited for the production of a wide number of complex chiral molecules with dense stereochemistry and functionality, which are motifs present in biologically active compounds and natural products. The book is divided into three principal sections, dealing successively with asymmetric domino reactions based on the use of chiral auxiliaries, asymmetric domino reactions based on the use of chiral metal catalysts, and asymmetric domino reactions based on the use of chiral organocatalysts, covering the literature since the beginning of 2006.
Helene Pellissier is a Researcher at the Centre National de la Recherche Scientifique (CNRS), where she focuses in organic synthesis.
1 Introduction; 2 Domino Reactions based on the use of Chiral Auxiliaries; 3 Domino Reactions based on the use of Chiral Metal Catalysts; 4 Domino Reactions based on the use of Chiral Organocatalysts; 5 Conclusions