This book is a comprehensive guide to the basic science of spinal diseases for trainees and clinicians. Divided into four sections, the authors begin with detailed discussion on the anatomy, physiology and pathophysiology of the intervertebral disc. The following sections examine the science of spinal instrumentation and spinal interventions.
Clinical chapters are structured in a uniform format, beginning with the presentation of a clinical case, followed by detailed discussion and supporting evidence. Each case ends with challenging questions to direct further investigation.
This book is a highly useful compilation of research work from recognised surgeons from the USA and The Netherlands, specialising in the fields of physiology, biology, biomechanics and mechanobiology.
Comprehensive guide to the basic science of spinal diseases
Based on research work of specialists in physiology, biology, biomechanics and mechanobiology
US and Dutch author and editor team
Includes nearly 240 full colour images and illustrations
Alok D Sharan MD Chief, Orthopedic Spine Service, Montefiore Medical Center; Assistant Professor, Albert Einstein College of Medicine, New York, USA Simon Y Tang PhD Assistant Professor, Orthopedic Surgery, Biomedical Engineering, Mechanical Engineering and Materials Science, Washington University, St Louis; Musculoskeletal Research Center, St Louis, Missouri, USA Alexander R Vaccaro MD PhD Thomas Jefferson University and the Rothman Institute, Philadelphia, Pennsylvania, USA
Section 1: Anatomy and Physiology of the Intervertebral Disc Anatomy and Structure of the Intervertebral Disc Biomechanics of Intervertebral Disc Vascular Anatomy of the Endplates and Nutrient Supply of the Disc Muscular Anatomy of the Spine Imaging of the Intervertebral Disc Animal Models for Disc Degeneration Animal Models of Back Pain and Sciatica Animal Models for Spinal Deformity and their Role in the Development of Surgical Nonfusion AIS Treatments Section 2: Pathophysiology of the Intervertebral Disc Pathophysiology of Disc Degeneration Genetics of Disc Degeneration The Role of Inflammation in Disc Degeneration Understanding the Pathways of Pain Treatment Strategies to Regenerate the IVD Section 3: The Science of Spinal Instrumentation Implant Properties of Spinal Instrumentation Biomechanics of Spinal Instrumentation Biomechanics of Cervical Spine Instrumentation Biomechanics of Thoracolumbar Instrumentation Biomechanics of Lumbar Interbody Fusion Biomechanics of Motion-Preserving Implants Biomechanics of Interspinous Process Devices Biomechanics of Cement Augmentation Implant Design and Testing Navigating the Regulatory and Reimbursement Pathways The Patent Process Section 4: The Science of Spinal Interventions Pharmaceutical Management of Spine Pain Biochemistry of Epidural Steroid Injections Basic Science of Discography and Provocative Testing The Use of Stem Cells in Spine Surgery Biology of Spinal Fusion Bone Graft Extenders