Calcium Orthophosphate-Based Bioceramics and Biocomposites

Calcium Orthophosphate-Based Bioceramics and Biocomposites

By: Sergey V. Dorozhkin (author)Hardback

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Description

Reflecting the advances made in recent years, this is a comprehensive overview of calcium orthophosphates for bioceramics and biocomposites with a special focus on the detailed description of all those available, including their biological and geological occurrence, preparation, chemical composition, structure-property relationships and applications. In particular, the book discusses the suitability of these orthophosphates for biomedical applications and their use as bone grafts in surgery and medicine. The result is a useful reference for researchers with an academic, medical or commercial background.

About Author

Sergey V. Dorozhkin received his MSc in chemical engineering with honors in 1984 from Moscow Institute of Chemical Technology, Moscow, Russia, and his PhD in chemistry in 1992 from the Research Institute of Fertilizers, Moscow, Russia. From 1992 to 1994 he worked as a senior researcher at the same institute, and from 1994 to 1996 he worked as a biotechnologist at a Swiss-Russia joint venture. From 1996 to 2004 he held five postdoctoral positions in France, Portugal, Germany and Canada where he worked on various aspects of calcium orthophosphates. Dr. Sergey V. Dorozhkin has authored more than seventy research papers, about twenty reviews, fifteen book chapters and three monographs.

Contents

Preface IX Part I Calcium Orthophosphates (CaPO4): Occurrence, Properties, and Biomimetics 1 1 Introduction 3 References 5 2 Geological and Biological Occurrences 7 References 11 3 The Members of CaPO4 Family 17 3.1 MCPM 18 3.2 MCPA (or MCP) 22 3.3 DCPD 22 3.4 DCPA (or DCP) 23 3.5 OCP 24 3.6 -TCP 25 3.7 -TCP 26 3.8 ACP 27 3.9 CDHA (or Ca-def HA, or CDHAp) 29 3.10 HA (or HAp, or OHAp) 31 3.11 FA (or FAp) 33 3.12 OA (or OAp, or OXA) 35 3.13 TTCP (or TetCP) 36 3.14 Biphasic, Triphasic, and Multiphasic CaPO4 Formulations 37 3.15 Ion-Substituted CaPO4 38 References 39 4 Biological Hard Tissues of CaPO4 59 4.1 Bone 61 4.2 Teeth 73 4.3 Antlers 80 References 83 5 Pathological Calcification of CaPO4 99 References 102 6 Biomimetic Crystallization of CaPO4 109 References 113 7 Conclusions and Outlook 121 References 123 Part II Calcium Orthophosphate Bioceramics in Medicine 125 8 Introduction 127 References 128 9 General Knowledge and Definitions 131 References 133 10 Bioceramics of CaPO4 135 10.1 History 135 10.2 Chemical Composition and Preparation 135 10.3 Forming and Shaping 137 10.4 Sintering and Firing 139 References 142 11 TheMajor Properties 159 11.1 Mechanical Properties 159 11.2 Electric/Dielectric and Piezoelectric Properties 162 11.3 Possible Transparency 163 11.4 Porosity 164 References 170 12 Biomedical Applications 189 12.1 Self-Setting (Self-Hardening) Formulations 196 12.2 Coatings, Films, and Layers 196 12.3 Functionally Graded Bioceramics 197 References 200 13 Biological Properties and In Vivo Behavior 205 13.1 Interactions with Surrounding Tissues and the Host Responses 205 13.2 Osteoinduction 207 13.3 Biodegradation 209 13.4 Bioactivity 211 13.5 Cellular Response 215 References 217 14 Nonbiomedical Applications of CaPO4 227 References 227 15 CaPO4 Bioceramics in Tissue Engineering 231 15.1 Tissue Engineering 231 15.2 Scaffolds and Their Properties 232 15.3 Bioceramic Scaffolds from CaPO4 235 15.4 A Clinical Experience 238 References 238 16 Conclusions and Outlook 253 References 255 Part III Biocomposites fromCalcium Orthophosphates 259 17 Introduction 261 Abbreviations 264 References 265 18 General Information and Knowledge 269 References 271 19 The Major Constituents of Biocomposites and Hybrid Biomaterials for Bone Grafting 275 19.1 CaPO4 275 19.2 Polymers 275 19.3 Inorganic Materials and Compounds 279 19.3.1 Metals 279 19.3.2 Glasses and Glass-Ceramics 279 19.3.3 Ceramics 280 19.3.4 Carbon 280 References 281 20 Biocomposites and Hybrid Biomaterials Based on CaPO4 287 20.1 Biocomposites with Polymers 287 20.1.1 Apatite-Based Formulations 292 20.1.2 TCP-Based Formulations 296 20.1.3 Formulations Based on Other Types of CaPO4 298 20.2 Self-Setting Formulations 299 20.3 Formulations Based on Nanodimensional CaPO4 and Nanodimensional Biocomposites 301 20.4 Biocomposites with Collagen 304 20.5 Formulations with Other Bioorganic Compounds and/or Biological Macromolecules 309 20.6 Injectable Bone Substitutes (IBSs) 312 20.7 Biocomposites with Glasses, Inorganic Compounds, Carbon, and Metals 313 20.8 Functionally Graded Formulations 318 20.9 Biosensors 321 References 322 21 Interaction among the Phases in CaPO4-Based Formulations 375 References 383 22 Bioactivity and Biodegradation of CaPO4-Based Formulations 391 References 393 23 Some Challenges and Critical Issues 395 References 396 24 Conclusions 399 References 400 Index 401

Product Details

  • ISBN13: 9783527337880
  • Format: Hardback
  • Number Of Pages: 416
  • ID: 9783527337880
  • weight: 1040
  • ISBN10: 3527337881

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