In the past 15 years parts of the cingulate cortex have been activated in thousands of neuroimaging studies and it has become a primary site of interest in structural and functional analyses of many neurological and psychiatric diseases. There are now more then 20 times the number of annual publications that analyse this region than there were 30 years ago.
There are many diseases that have an early and direct impact on the cingulate cortex, including, chronic pain and stress syndromes, depression, obsessive-compulsive and attention-deficit/hyperactivity disorders, and neurodegenerative diseases such as schizophrenia, mild cognitive impairment, dementia with Lewy bodies, and Alzheimer's disease.
This major new text brings together cutting-edge information on the human cingulate cortex and its diseases as written by the leading authorities, and synthesizes these with other approaches - including neurophysiology and neuroanatomy in experimental animals; mainly in monkeys. The book considers cingulate infrastructure in terms of its cytology, receptor binding and circuitry, including functions such as emotion and autonomic and skeletomotor regulation, pain processing and chronic stress
syndromes, cognition, and visuospatial orientation.
Cingulate Neurobiology and Disease is a major publication in neuroscience, one that will have a major influence on research for years to come.
PART I - STRUCTURAL ORGANIZATION ; 1. Regions and subregions of the cingulate cortex ; 2. Transmitter receptor systems in cingulate regions and areas ; 3. Architecture, cytology and comparative organization of primate cingulate cortex ; 4. Thalamocingulate connections in the monkey ; 5. Cingulofrotnal interactions and the cingulate motor areas ; 6. Temporocingulate interactions in the monkey ; 7. Dopamine in the cingulate gyrus: organization, development and neurotoxic vulnerability ; PART II - EMOTION AND COGNITION ; 8. The antierior and midcingulate cortices and reward ; 9. CinguloAmygdala interactions in surprise qne extinctions: interpreting associative ambiguity ; 10. Visceral circuits, autonomic functions and human imaging ; 11. The cingulate cortex as organizing principle in neuropsychiatric disease ; 12. Dorsal anterior midcingulate cortex: roles in normal cognition and disruption in ADHD ; 13. The primate posterior cingulate gyrus: connections, sensorimotor orientation, gateway to limbic processing ; PART III - PAIN: NEUROMATRIX, SYNDROMES AND TREATMENT ; 14. Medial nociceptive circuitry and roles of cingulate cortex in pain: afferent sustems and the cingulate premotor pain model ; 15. Opioids, placebos and descending control of pain systems ; 16. Pain anticipation in the cingulate cortex ; 17. Hypnosis and cingulate-mediated mechanisms of analgesia ; 18. Neurophysiology of cingulate pain responses and neurosurgical pain interventions ; 19. The role of the cingulate cortex in central neuropathic pain: functional imaging and cortical model of allodynia ; 20. Thalamocingulate mechanisms of precentral cortex stimulation for central pain ; PART IV - STRESS: SYNDROMES AND CIRCUITS ; 21. The role of the anterior cingulate cortex in posttraumatic stress and panic disorders ; 22. Noradrenergic-cingulate circuit interactions as sites of chronic pain and stress vulnerabilities ; 23. Impact of functional visceral and somatic pain/stress syndromes on cingulate cortex ; PART V - ALTERED MOTIVATION, COGNITION AND MOVEMENT ; 24. The role of the cingulate gyrus in depression: review and synthesis of imaging data ; 25. Cingulate neuropathological substrates of depression ; 26. Altered processisn of valnce and sisgnificance-coded information in the psychopathic cingulate gyrus ; 27. The role of cingulate cortex dysfunction in obsessive-compulsive disorder ; 28. The contribution of anterior cingulate-basal ganglia circuitry to complex behavior and psychiatric disorders ; 29. Cingulate cortex seizures ; VI - NEURODEGENERATIVE DISEASES: PSYCHOSIS AND DEMENTIA ; 30. The cingulate gyrus in schizophrenia: imaging altered structure and functions ; 31. Course and pattern of cingulate pathology in schizophrenia ; 32. Cingulate subregional neuropathology in dementia with Lewy bodies and Parkinson's disease with dementia ; 33. Mild cognitive impairment: pivotal cingulate damage in amnesic and dysexecutive subgroups ; 34. Brain imaging in prodromal and probable Alzheimer's disease: a focus on the cingulate gyrus ; 35. Cingulate neuropathology in Alzheimer's disease ; PART VII - IMAGING APPENDIX ; 36. Localizing cingulate subregions of interest - SOIs - in magnetic resonance images guided by cytological parcellations