A presentation of total syntheses from organic chemists, analyzing each retrosynthetically to make strategies more accessible. The authors give hints on alternative methods and potential pitfalls. Emphasis is placed on the use of graphics and schemes: reaction sequences and synthetically crucial steps are presented in blue boxed sections; important formulas are, in addition, depicted in the margin, next to the passage where they are mentioned in the text.
K. C. Nicolaou is Professor of Chemistry at the University of California, San Diego and is Chairman of the Department of Chemistry and holds the Skaggs Professorship of Chemical Biology and the Darlene Shiley Chair in Chemistry at The Scripps Research Insitute. His impact on chemistry flows from his works in chemical synthesis and chemical biology described in over 550 publications and 55 patents.
Constructing the molecules of nature; strychnine; penicillin; reserpine; prostaglandin F2a and E2; progesterone; carpanone; Vitamin B12; prostaglandin A2 and F2a; estrone; erythronolide B; monensin; periplanone B; isocomene; monensin; thienamycin; endiandric acids; biotin; L-hexoses; asteltoxin; periplanone B; menthol; amphoteronolide B and amphotericin B; ginkgolide B; methyl homosecodaphniphllate; indolizomycin; cytovaricin; gilvocarcin M and V; rapamycin; paeoniflorigenin and paeoniflorin; strychnine; taxol; zaragozic acid A / squalestatin S1; palytoxin; brevetoxin B. (Part contents).