Comprehensive Biomarker Discovery and Validation for Clinical Application (Volume 33)

Comprehensive Biomarker Discovery and Validation for Clinical Application (Volume 33)

By: Peter Horvatovich (editor), Rainer Bischoff (editor), Diamandis Diamandis (contributor), Fournier Fournier (contributor), Ana Martinez (series_editor), Professor Robin Ganellin (series_editor), David P. Rotella (series_editor), David Fox (series_editor), Salvatore Guccione (series_editor), David E. Thurston (series_editor)Hardback

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Description

1. This book discusses biomarker discovery and validation procedures 2. Biomarker discovery and validation is important for drug discovery 3. Medicinal and biochemists in academia and industry 4. Issues in Toxicology, toxicology research 5. Focussed on the present methodology and theory of operations of biomarker discovery and validation research.

About Author

Peter Horvatovich and Rainer Bischoff have worked at the University of Groningen Faculty of Mathematics and Natural Science for more than five years. Rainer Bischoff is professor in analytical biochemistry and has been studying protein analysis and proteomics for over 20 years. He obtained his PhD at the University of G??ttingen before undertaking postdoctoral research at Purdue University in the USA. He also worked as a group and project leader at Transgene S. A. in Strasburg and a section manager at AstraZeneca R&D in Lund. Peter Horvatovich is an Assistant Professor. He has studied proteomics related bioinformatics for more than eight years and has an analytical chemistry background. Dr Horvatovich received his PhD at the University of Strasbourg for work related to the detection of irradiated food. He then worked at Sanofi-Synthelabo in Budapest and as a postdoctoral researcher at the Bundesinstitute fur Risikobewertung in Berlin before moving to the University of Groningen.

Contents

Introduction to biomarker discovery and validation; Clinical context of proteomics biomarker discovery and validation, authority regulations; Biomarker discovery: Patient selection; Biomarker discovery: Experimental design and biobanking; Biomarker discovery: body fluids; Biomarker discovery: tissues; Biomarker discovery: mass spectrometry based profiling platforms; Biomarker discovery: array based profiling platforms; Biomarker discovery: data preprocessing for LC-MS data; Biomarker discovery: data preprocessing for Maldi imaging, and 2D electrophoresis and protein arrays data; Biomarker discovery: statistical analysis and validation; Biomarker validation: biomarker validation methods; Functional biomarker validation; Clinical application: case studies Clinical application: summary and future technology development trends

Product Details

  • ISBN13: 9781849734226
  • Format: Hardback
  • Number Of Pages: 384
  • ID: 9781849734226
  • weight: 720
  • ISBN10: 1849734224

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