Biophysics is a rapidly-evolving interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. Biophysics encompasses many disciplines, including physics, chemistry, mathematics, biology, biochemistry, medicine, pharmacology, physiology, and neuroscience, and it is essential that scientists working in these varied fields are able to understand each other's research. Comprehensive Biophysics will help bridge that communication gap.
Written by a team of researchers at the forefront of their respective fields, under the guidance of Chief Editor Edward Egelman, Comprehensive Biophysics provides definitive introductions to a broad array of topics, uniting different areas of biophysics research - from the physical techniques for studying macromolecular structure to protein folding, muscle and molecular motors, cell biophysics, bioenergetics and more. The result is this comprehensive scientific resource - a valuable tool both for helping researchers come to grips quickly with material from related biophysics fields outside their areas of expertise, and for reinforcing their existing knowledge.
Edward Egelman received a BA in physics and a PhD in biophysics from Brandeis University. He was a postdoctoral fellow at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, and then an assistant professor at Yale University. He was an associate and full professor at the University of Minnesota Medical School, and then moved to the University of Virginia in 1999 where he is a professor of biochemistry and molecular genetics. He is currently editor-in-chief of Biophysical Journal. He has been elected a fellow of the Biophysical Society and of the American Academy of Microbiology. His research focuses on the structure and function of macromolecular complexes, mainly using electron cryo-microscopy and computational image analysis. He has spent many years studying the structure of F-actin, as well as helical nucleoprotein complexes formed by recombination proteins (such as the bacterial RecA and the eukaryotic Rad51) on DNA.
X-ray crystallography NMR Spectroscopy Electron microscopy Mass spectrometry SAXS Ultrafast spectroscopic techniques EPR and Other electron spectroscopies Computation Fast flow Other spectroscopy - UV-Vis, CD, Raman, vibrational CD FRET/fluorescence Elucidating cellular structures Protein Folding Globular Proteins Nucleic Acid Folding General Theoretical Considerations Actin Microtubules Myosin Muscle Non-Muscle Motility Kinesin Dynein Nucleic Acid Motors Lipid Bilayers Membrane Proteins Protein Interactions with Membranes Membrane Conformational Transitions Membrane Dynamics Lipid Bilayers Molecular Modeling approaches to understand mechanisms in Voltage-Gated Channels Connexin Channels Structure-function correlates of Glutamate-Gated ion channels TRP channels Mechanotransduction Structure and mechanisms in chloride channels Biophysics of Ceramide Channels Proton channels Structure-function correlates of voltage-gated potassium channels Store-operated Calcium Channels Bacterial Toxin channels Viral channels Structure-Function Correlates in Plant Channels | Plant channels Biophysics of cell-matrix adhesion Biophysics of selectin-mediated cell-cell adhesions Biophysics of cadherin-mediated cell-cell adhesion Biophysics of cell division Biophysics of bacterial cell growth and division Biophysics of three-dimensional cell motility Biophysics of molecular cell mechanics Biophysics of nuclear organization and dynamics Cell-extracellular matrix mechanobiology in cancer Biophysics of cell motility Biophysics of cell developmental processes Biophysics of bacterial organization Structure-function relationships in P-type ATPases Rotational catalysis by the ATP synthase Bacterial rotary flagellar motor Electron transport chains Light capture - photos Photosystems of bacteria and plants A B C Transporters The mitochondrial family of transport proteins Bacteriorhodopsin and Related Proteins Theory of transport processes Structure function relationships in membrane transport prtotreins of the MFS and leu-T families (approximate) In silico approches to structure and function of cell components and their aggregates Simulations of molecular machines In silico approches to structure and function of cell components and their assemblies Modeling of interaction networks in the cell Mathematical modeling of complex biological systems