Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery (Advances in Pharmaceutical Technology)

Computational Pharmaceutics: Application of Molecular Modeling in Drug Delivery (Advances in Pharmaceutical Technology)

By: Defang Ouyang (editor), Sean C. Smith (editor), Alfred Fahr (series_editor), Martin J. Snowden (series_editor), Dennis Douroumis (series_editor), Juergen Siepmann (series_editor), Vladimir Torchilin (series_editor)Hardback

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Description

Molecular modeling techniques have been widely used in drug discovery fields for rational drug design and compound screening. Now these techniques are used to model or mimic the behavior of molecules, and help us study formulation at the molecular level. Computational pharmaceutics enables us to understand the mechanism of drug delivery, and to develop new drug delivery systems. The book discusses the modeling of different drug delivery systems, including cyclodextrins, solid dispersions, polymorphism prediction, dendrimer-based delivery systems, surfactant-based micelle, polymeric drug delivery systems, liposome, protein/peptide formulations, non-viral gene delivery systems, drug-protein binding, silica nanoparticles, carbon nanotube-based drug delivery systems, diamond nanoparticles and layered double hydroxides (LDHs) drug delivery systems. Although there are a number of existing books about rational drug design with molecular modeling techniques, these techniques still look mysterious and daunting for pharmaceutical scientists. This book fills the gap between pharmaceutics and molecular modeling, and presents a systematic and overall introduction to computational pharmaceutics. It covers all introductory, advanced and specialist levels. It provides a totally different perspective to pharmaceutical scientists, and will greatly facilitate the development of pharmaceutics. It also helps computational chemists to look for the important questions in the drug delivery field. This book is included in the Advances in Pharmaceutical Technology book series.

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Contents

Chapter 1. Introduction of computational pharmaceutics Defang Ouyang Chapter 2. Crystal energy landscapes for aiding crystal form selection Sarah Price Chapter 3. Solubilization of poor-soluble drugs in cyclodextron formulation Defang Ouyang Chapter 4. Molecular Modeling for Polymeric and Micellar Drug Delivery Sharon M. Loverde Chapter 5. Solid dispersion - a pragmatic method to improve the bioavailability of poorly soluble drugs Defang Ouyang Chapter 6. Computer simulations of lipid membranes and liposomes for drug delivery Becky Notman Chapter 7. Molecular modeling for protein aggregation and formulation Jim Warwicker Chapter 8. Computational simulation of drug delivery by nano-materials at molecular level Youyong Li Chapter 9. Molecular and analytical modeling of nanodiamond for drug delivery applications Amanda Barnard Chapter 10. Molecular modeling of LDH drug delivery systems Vinuthaa Murthy Chapter 11. Molecular dynamics simulation as a tool to study the efficacy of PEGylation Alex Bunker Chapter 12. Synchrotron Radiation Micro Computed Tomography: a new approach for quantitative 3D structural architecture of drug delivery systems Jiwen Zhang Chapter 13. Pharmacokinetic modelling and simulation in drug delivery Raj Index

Product Details

  • publication date: 17/07/2015
  • ISBN13: 9781118573990
  • Format: Hardback
  • Number Of Pages: 340
  • ID: 9781118573990
  • weight: 674
  • ISBN10: 1118573994

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