Contemporary Drug Synthesis (Wiley Series on Drug Synthesis)

Contemporary Drug Synthesis (Wiley Series on Drug Synthesis)

By: Drago R. Sliskovic (author), Bruce D. Roth (author), Jie Jack Li (author), Douglas S. Johnson (author)Hardback

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An integrated and insightful look at successful drug synthesis in today's drug discovery market The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug. Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry's most respected scientists, this timely volume: * Focuses on the processes that resulted in high-profile drugs including Lipitor, Celebrex, Viagra, Gleevec, Nexium, Claritin, and over a dozen others * Provides an in-depth introduction to each drug, followed by a detailed account of its synthesis * Organizes the drugs into fourteen therapeutic areas for clarity and ease of useProcess chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

About Author

JIE-JACK LI, PhD, DOUGLAS S. JOHNSON, PhD, DRAGO R. SLISKOVIC, PhD, AND BRUCE D. ROTH, PhD, are all members of Pfizer Global Research and Development, and are among the most prominent scientists working in drug discovery today.


Preface. Trade Names and Their Corresponding USANs. Acronyms and Abbreviations. Chapter 1. Antithrombotics: Ticlopidine (Ticlid(r)) and Clopidogrel (Plavix(r)). Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex(r)) and Rofecoxib (Vioxx(r)). Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium(r)). Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec(r)) and Gefitinib (Iressa(r)). Chapter 5. Non-sedating Antihistamines. Chapter 6. Cosmeceuticals: Istretinoin (Accutane(r)), Tazarotene (Tazorac(r)), Minoxidil (Rogaine(r)), and Finasteride (Propecia(r)). Chapter 7. Antibacterials: Ciprofloxacin (Cipro(r)) and Linezolid (Zyvox(r)). Chapter 8. Atypical Antupsychotics. Chapter 9. Atovastatin Calcium (Lipitor(r)). Chapter 10. Antidepressants. Chapter 11. Anti-obesity: Orlistat (Xenical(r)). Chapter 12. Triptans for Migrane. Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra(r)), Vardenafil (Levitra(r)), and Tadalafil (Cialis(r)). Chapter 14. Antiasthmatics. Index.

Product Details

  • ISBN13: 9780471214809
  • Format: Hardback
  • Number Of Pages: 240
  • ID: 9780471214809
  • weight: 656
  • ISBN10: 0471214809

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