Controlled Drug Delivery: Challenges and Strategies (ACS Professional Reference Book)

Controlled Drug Delivery: Challenges and Strategies (ACS Professional Reference Book)

By: Kinam Park (editor)Hardback

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Description

This volume discusses the challenges of creating controlled release dosage forms that will deliver new therapeutic agents based on high-molecular-weight molecules. It examines strategies for delivering drugs through resistant biological barriers and surveys a variety of topics, including drug targeting, self-regulated drug delivery, protein drug delivery, biosensors, cell and tissue engineering, new biomaterials, modeling methods, pharmacokinetics, and U.S. federal regulations.

Contents

CONTROLLED DRUG DELIVERY: PAST, PRESENT, AND FUTURE ; INTRACELLULAR DELIVERY AND TARGETING ; 2. Intracellular Delivery of Peptides and Proteins ; 3. DNA Delivery Vectors for Somatic Cell Gene Therapy ; 4. Targetable Polymeric Drugs ; 5. Particle Engineering of Biodegradable Colloids for Site-Specific Drug Delivery ; 6. Site-Specific Drug Delivery in the Gastrointestinal Tract ; SELF-REGULATED DRUG DELIVERY ; 7. Feedback-Controlled Drug Delivery ; 8. Stimuli-Sensitive Drug Delivery ; 9. Sensocompatibility: Design Considerations for Biosensor-Based Drug Delivery Systems ; DELIVERY OF PEPTIDE AND PROTEIN DRUGS ; 10. Formulation of Proteins and Peptides ; 11. Stability of Peptides and Proteins ; 12. Peptide, Protein, and Vaccine Delivery from Implantable Polymeric Systems ; 13. Oral Immunization Using Microparticles ; 14. Peptide and Protein Delivery for Animal Health Applications ; TISSUE ENGINEERING AND GENE THERAPY ; 15. Protein Delivery by Microencapsulated Cells ; 16. Tissue Engineering: Integrating Cells and Materials To Create Functional Tissue Replacements ; 17. Drug Delivery Using Genetically Engineered Cell Implants ; 18. Ribozymes as Antiviral Agents ; NEW BIOMATERIALS FOR DRUG DELIVERY ; 19. Pseudo-Poly(amino acid)s: Examples for Synthetic Materials Derived from Natural Metabolites ; 20. Transductional Protein-Based Polymers as New Controlled-Release Vehicles ; 21. Synthetically Designed Protein Polymer Biomaterials ; 22. Biological Effects of Polymeric Drugs ; 23. New Biodegradable Polymers for Medical Applications: Elastomeric Poly(phosphoester-urethane)s ; 24. "Intelligent" Polymers ; MODELING OF CONTROLLED DRUG DELIVERY ; 25. Modeling of Self-Regulating Oscillatory Drug Delivery ; 26. Modeling Studies of Future Controlled-Release Devices ; 27. Computer Dynamics Simulation of Controlled Release ; REGULATORY ISSUES ; 28. Food and Drug Regulations for Controlled-Release Dosage Forms ; 29. Pharmacodynamic and Pharmacokinetic/ Considerations in Controlled Drug Delivery

Product Details

  • ISBN13: 9780841234185
  • Format: Hardback
  • Number Of Pages: 720
  • ID: 9780841234185
  • weight: 1283
  • ISBN10: 0841234183

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