Depression has become a major international health issue and should be a concern of every nurse, regardless of specialty. While physicians are focused on etiology and medical treatment, nurses must attend to how people express and deal with this crippling illness. This volume provides new knowledge about depression that can be translated into clinical care on both the individual and community level. This book sheds light on this debilitating chronic disorder and will help guide the understanding and approach to a person with depression. While there is evidence that depression is manifested differently by characteristics, such as gender, race, and culture, we know very little about the mechanisms, both biological and socio-cultural, that create or contribute to these differences. The research included maintains an international perspective with a broad focus on special populations and multicultural groups.