Two key aspects of how the body handles drugs and other chemicals are metabolism and transport. The remarkable advances in molecular and cell biology and the development of novel in vitro model systems to study the various processes involved in metabolism and transport have expanded our knowledge and led to numerous, new therapeutic approaches to treatment of chemically-induced toxicity and disease. This book presents a collection of reviews on important topics in metabolism and transport. The editor has selected several of the major drug metabolizing systems, including the cytochrome P450 family, flavin-containing monooxtgenases, glutathione S-transferases, glucuronidation, N-acetylation, and sulfotransferases. Additional chapters present approaches to the study of signaling pathways in the regulation of drug metabolism enzymes and how modulation of these pathways can influence antiviral therapy. The transport chapters cover multidrug resistance proteins, the reduced folate carrier, and plasma membrane and mitochondrial glutatione transporters.
Renal Cytochrome P450s and Flavin-Containing Monooxygenases: Potential Roles in Metabolism and Toxicity of 1,3-Butadiene, Trichloroethylene, and Tetrachloroethylene; Adnan A. Elfarra; Experimental Approaches for the Study of Cytochrome P450 Gene Regulation; Hollie I. Swanson, S.D. Kraner, S.S. Ray, M. Hoagland, E.D. Thompson, X. Zheng, and Y. Tian; Insulin and Growth Factor Signaling: Effects on Drug Metabolizing Enzymes; Sang K. Kim, Kimberly J. Woodcroft, and Raymond F. Novak; Catalytic Function and Expression of Glutathione Transferase Zeta; Philip G. Board, M.W. Anders, and Anneke C. Blackburn; Glucuronidation of Fatty Acids and Prostaglandins by Human UDP-Glucuronosyltransferases; Anna Radominska-Pandya, Joanne M. Little, and Arthur Bull; Transcriptional Regulation of UDP-Glucuronosyltransferases; Anna Radominska-Pandya, Peter I. Mackenzie, and Wen Xie; Phenotypic and Genotypic Characterization of N-Acetylation; Craig K. Svensson and David W. Hein; Methods and Approaches to Study Metabolism and Toxicity of Acetaminophen; Sam A. Bruschi; Modulation of Drug Metabolism and Antiviral Therapies; Bernhard H. Lauterburg; Modulation of Thiols and Other Low-Molecular-Weight Cofactors: Effects on Drug Metabolism and Disease Susceptibility; Charles V. Smith; Multidrug Resistance Proteins and Hepatic Transport of Endo- and Xenobiotics; Phillip M. Gerk and Mary Vore; Structural Determinants of Folate and Antifolate Membrane Transport by the Reduced Folate Carrier; Wei Cao and Larry H. Matherly; Glutathione Transport in the Kidneys: Experimental Models, Mechanisms, and Methods; Lawrence H. Lash; Human Cytosolic Sulfotransferases: Properties, Physiological Functions, and Toxicology; Charles N. Falany