Engineering Neural Tissue from Stem Cells covers the basic knowledge needed to understand the nervous system and how existing cells can be used to create neural tissue. This book presents a broad range of topics related to the design requirements for engineering neural tissue from stem cells. It begins with the anatomy and function of the central and peripheral nervous system, also covering stem cells, their relation to the nervous system and their function in recovery after injury or disease. In addition, the book explores the role of the extracellular matrix and vasculature/immune system and biomaterials, including their suitability for neural tissue engineering applications.
Dr. Stephanie Willerth currently holds a Canada Research Chair in Biomedical Engineering at the University of Victoria where she is dually appointed in the Department of Mechanical Engineering and Division of Medical Sciences. Her interdisciplinary research group investigates how to engineer neural tissue by combining pluripotent stem cells, controlled drug delivery and biomaterial scaffolds. In 2014, she was named a "Star in Global Health" by Grand Challenges Canada and in 2015, she was named a Young Innovator in Cellular and Molecular Biology. She is an active member in the International Collaboration on Repair Discoveries (ICORD), a B.C. based organizations committed to finding long term treatment for the repair of spinal cord injuries. Before accepting her faculty position, Dr. Willerth completed a National Institutes of Health sponsored post-doctoral fellowship at the University of California-Berkeley and graduate studies at Washington University. She received undergraduate degrees in Biology and Chemical Engineering from the Massachusetts Institute of Technology.
1. The need for engineering neural tissue using stem cells 2. Overview of the nervous system 3. Stem cells and their applications in repairing the damaged nervous system 4. Design considerations when engineering neural tissue from stem cells 5. Natural biomaterials for engineering neural tissue from stem cells 6. Synthetic biomaterials for engineering neural tissue from stem cells 7. Drug delivery systems for engineering neural tissue 8. New technologies for engineering neural tissue from stem cells