Enzybiotics, by using enzymes to fight bacteria, offer a novel and promising new way to combat infectious diseases. This book presents the state-of-the-art and therapeutic potential of enzybiotics, with a stress on therapeutic applications. The coverage offers a unique combination of medicinal chemistry, microbiology, genetics, and biochemistry. It also addresses the timely topic of bacterial resistance to antibiotics, and provides readers with a novel angle to study and combat infectious diseases.
Tomas G. Villa, PhD, is Full Professor of Microbiology and Chair of the Department of Microbiology at the University of Santiago de Compostela, Faculty of Pharmacy (Spain). Dr. Villa has written twenty book chapters and over 160 papers. In addition, he has translated into Spanish several microbiology text books. Dr. Villa is regularly engaged in the teaching of microbiology and biotechnology. Patricia Veiga-Crespo, PhD, is Lecturer of Microbiology and works in the Department of Microbiology at the University of Santiago de Compostela, where she is involved in the study of multi-resistance phenomena and enzybiotics and the teaching of advanced biotechnology and basic microbiology.
PREFACE. CONTRIBUTORS. 1 ENZYBIOTICS AND THEIR POTENTIAL APPLICATIONS IN MEDICINE (Jan Borysowski and Andrzej Gorski). 2 ADVANTAGES AND DISADVANTAGES IN THE USE OF ANTIBIOTICS OR PHAGES AS THERAPEUTIC AGENTS (Patricia Veiga-Crespo and Tomas G. Villa). 3 ENZYBIOTICS AS SELECTIVE KILLERS OF TARGET BACTERIA (Juan C. Alonso and Marcelo E. Tolmasky). 4 PHYLOGENY OF ENZYBIOTICS (Patricia Veiga-Crespo and Tomas G. Villa). 5 BACTERIOPHAGE LYSINS: THE ULTIMATE ENZYBIOTIC (Vincent A. Fischetti). 6 BACTERIOPHAGE HOLINS AND THEIR MEMBRANEDISRUPTING ACTIVITY (Maria Gasset). 7 ANTI-STAPHYLOCOCCAL LYTIC ENZYMES (Jan Borysowski and Andrzej Gorski). 8 MEMBRANE-TARGETED ENZYBIOTICS (Maria Gasset). 9 DESIGN OF PHAGE COCKTAILS FOR THERAPY FROM A HOST RANGE POINT OF VIEW (Lawrence D. Goodridge). 10 IDENTIFYING PHAGE LYTIC ENZYMES: PAST, PRESENT, AND FUTURE (Jonathan E. Schmitz, Raymond Schuch, and Vincent A. Fischetti). 11 USE OF GENETICALLY MODIFIED PHAGES TO DELIVER SUICIDAL GENES TO TARGET BACTERIA (Lawrence D. Goodridge). CONCLUDING REMARKS: THE FUTURE OF ENZYBIOTICS (Patricia Veiga-Crespo and Tomas G. Villa). INDEX.