Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector.
The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver).
The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer.
1. Introduction 2. DNA Methylation & Hydroxymethylation in Cancer 3. Writers, Readers, and Erasers of Epigenetic Marks 4. MicroRNAs and Cancer 5. Long Noncoding RNAs (lncRNAs) and Cancer 6. Ribosomal RNA Methylation and Cancer 7. Mining the Epigenetic Landscape: Surface Mining or Deep Underground 8. Development of Epigenetic Targeted Therapies in Hematological Malignancies: From Serendipity to Synthetic Lethality 9. Epigenetic Therapy in Lung Cancer and Mesothelioma 10. Breast Cancer Epigenetics 11. Therapeutic Applications of the Prostate Cancer Epigenome 12. Liver Cancer (Hepatocellular Carcinoma) 13. Neuroblastoma 14. The Epigenetics of Medulloblastoma 15. Clinical Significance of Epigenetic Alterations in Glioblastoma 16. Esophageal Cancer 17. Nasopharyngeal Cancer 18. Nutritional Epigenetic Inhibitors in the Field of Cancer: New Avenues for Chemopreventive Approaches 19. Emerging Epigenetic Therapies - Lysine Methyltransferase/PRC Complex Inhibitors 20. Inhibitors of Jumonji C Domain Histone Demethylases 21. Emerging Epigenetic Therapies - Lysine Acetyltransferase Inhibitors 22. Emerging Epigenetic Therapies - Bromodomain Ligands 23. Clinical Trials 24. Genetic Intratumor Heterogeneity 25. Epigenetics Underpinning DNA Damage repair 26. Epigenetics of Cisplatin Resistance 27. Therapeutically Targeting Epigenetic Regulation of Cancer Stem Cells 28. Personalized Therapy - Chemosensitivity Testing 29. Personalized Therapy - Epigenetic Profiling as Predictors of Prognosis and Response