After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.
Alexander G Haslberger is group leader at the Department for Nutritional Sciences at the University of Vienna where he also received his academic degrees. He worked in research groups of the Sandoz Research Inst., the University of Minnesota, the WHO in Geneva and headed a group at the Fed. Ministry of Health, Vienna. He participated in the preparation of the WHO report on modern food biotechnology, the UN Millennium Ecosystem Assessment, the preparation of the OECD conference on genetic testing, Vienna 2000, the Public Health Genomic EC network, EC research projects and in WHO expert groups.
GENERAL INTRODUCTION The research program in epigenetics: the birth of a new paradigm (Vineis) Interactions between nutrition and health (Elmadfa) Epigenetics: Comments from an Ecologist (Schiemer) Interaction of hereditary and epigenetic mechanisms in gene expression (Haslberger) HEREDITARY ASPECTS Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and cancer risk: a review of the published meta-analyses (Boccia) The Role of Biobanks for the Understanding of Gene-Environment Interactions (Zatloukal) Case studies on epigenetic inheritance (Kaati) ENVIRONMENTAL AND TOXICOLOGICAL ASPECTS Genotoxic, non-genotoxic and epigenetic mechanisms in chemical hepatocarcinogenesis: Implications for safety evaluation (Bursch) Carcinogens in foods: occurrence, modes of action and modulation of human risks by genetic factors and food components (Knasmuller) NUTRITIONAL ASPECTS From molecular nutrition to nutritional systems biology (Vergeres) Effects of dietary natural compounds on DNA methylation related to cancer chemoprevention and anticancer epigenetic therapy (Stefanska) Health determinants throughout the life cycle (Rust) CASE STUDIES Viral infections and epigenetic control mechanisms (Klaus Huber) Epigenetic aspects in gynaecology and reproductive medicine (Johannes Huber) Epigenetics and Tumorigenesis (Karlic) Epigenetic approaches in oncology (Mader) Epigenetic Dysregulation in Aging and Cancer (Komninou) The impact of genetic and environmental factors in neurodegeneration: emerging role of epigenetics (Migliore) Epigenetic biomarkers in neurodegenerative disorders (Peterlin) Epigenetic mechanisms in asthma (Miller) WAYS FOR TRANSLATION OF THE CONCEPT Public Health Genomics - Integrating Genomics and Epigenetics into National and European Health Strategies and Policies (Schulte in den Baumen) Taking a first step: epigenetic health and responsibility (Gesche)