Epigenetics and Psychiatric Disease, Volume 157, the latest volume in the Progress in Molecular Biology and Translational Science series, includes recent developments on a variety of topics, including the Epigenetic landscapes of the adversity-exposed brain, Chromosomal conformations and epigenomic regulation in schizophrenia, Progress in the epigenetics of depression, the epigenetics of circadian rhythms in imprinted neurodevelopmental disorders, DNA methylation mediating substance abuse, mechanisms and therapeutic opportunities, DNA methylation in animals model of psychosis, Epigenetics of early life stress, Epigenetic drugs for mood disorders, and more.
Dr. Grayson has been interested in mechanisms associated with gene expression for over 20 years. He joined the laboratory of Dr. James E. Darnell, Jr. at the Rockefeller University on 1984 to study cell-type specific transcription factors. This led to the identification of HNF3A as a hepatocyte nuclear factor important for activating the expression of multiple genes in hepatocytes. In 1988, Dr. Grayson joined the Fidia-Georgetown Institute for the Neurosciences and with the support of Dr. Erminio Costa, initiated a program in studying gene expression in neurons. From 1994-1998, he moved to the Allegheny University of the Health Sciences in Pittsburgh and developed a program in molecular psychiatry. He continued his interests in psychiatry and joined the Psychiatric Institute in 1998. This represented a unique opportunity to join his long time collaborators, Drs. Costa and Guidotti to pursue molecular underpinnings of schizophrenia. Dr. Grayson has received NRSA post-doctoral support, R01 and K04 funding from the NIH over the years. He has published over 100 papers in peer-reviewed journals and actively reviews NIH grants and post-doctoral fellowships. In addition, Dr. Grayson has been invited to speak at numerous national and international meetings.
1. Epigenetic Landscapes of the Adversity-exposed Brain Tania L. Roth 2. Chromosomal Conformations and Epigenomic Regulation in Schizophrenia Schahram Akbarian 3. Progress in Epigenetics of Depression Eric J. Nestler 4. Epigenetics of circadian rhythms in imprinted neurodevelopmental disorders Janine M. LaSalle 5. DNA methylation mediating substance abuse; mechanisms and therapeutic opportunities Moshe Szyf 6. DNA Methylation in Animals Model of Psychosis Alessandro Guidotti and Dennis R. Grayson 7. Epigenetics of early life stress Chris Murgatroyd 8. Epigenetic Drugs for Mood Disorders Jacob Peedicayil 9. Behind Epigenetic Alterations in Psychiatric Diseases Hamid M. Abdolmaleky 10. DNA methylation and its possible role in psychiatric disorders Chunyu Liu 11. Neuroepigenetics of suicide brain ogesh Dwivedi 12. Epigenetic Mechanisms of Traumatic Brain Injuries Amul Sakharkar 13. Non-protein-coding RNAs in Fetal Alcohol Spectrum Disorders Rajesh C. Miranda 14. Targeting histone-modifications as a therapeutic approach to treat psychosis Andre Fischer 15. The epigenetics of early life adversity: current limitations and possible solutions Gustavo Turecki