Recent years have seen spectacular advances in the filed of epigenetics. These have attracted the interest of researchers in many fields and evidence connecting epigentic regulation to brain functions has been accumulationg. Neurons daily convert a variety of external stimuli into rapid or long-lasting changes in gene expression. A variety of studies have centered on the molcular mechanisms implicated in epigentic control and how these may operte in concert. It will be critical to unravel how specifity is achieved. The focus of this volume is on critical epigenetic regulation and chromatin remodeling events that occur in the nervous system and on the presumed mechanisms that operate within neurons to translate them into long-lasting neuronal responses.
Foreword.- Nucleosome Remodelling and Epigenome Diversification.- Synaptic Epigenesis and the Evolution of Higher Brain Functions.- Plasticity of the Circadian System: Linking Metabolism to Epigenetic Control.- Epigenetics and the Environmental Regulation of Genomic Structure and Function: Implications for Health.- Epigenetic Inheritance in Mammals.- Control of Neuronal Gene Transcription and Behavior by the Epigenetic Suppressor Complex G9a/GLP.- r The Role of Histone Acetylation in Long-term Memory Storage.- DNA Methylation in Memory Formation.- Epigenetic Mechanisms Regulating Memory Formation In Health and Disease.- Genetics and Epigenetics of Autism Spectrum Disorders.- Analysis of MeCP2 Function in the CNS.- Epigenetic Mechanisms of Drug Addiction.- Subject index