Illuminating the processes and patterns that link genotype to phenotype, "Epigenetics" seeks to explain features, characters, and developmental mechanisms that can only be understood in terms of interactions that arise above the level of the gene. With chapters written by leading authorities, this volume offers a broad integrative survey of epigenetics. Approaching this complex subject from a variety of perspectives, it presents a broad, historically grounded view that demonstrates the utility of this approach for understanding complex biological systems in development, disease, and evolution. Chapters cover such topics as morphogenesis and organ formation, conceptual foundations, and cell differentiation, and together demonstrate that the integration of epigenetics into mainstream developmental biology is essential for answering fundamental questions about how phenotypic traits are produced.
Benedikt Hallgrimsson, Professor in the Department of Cell Biology and Anatomy at the University of Calgary, is coeditor of Variation: A Central Concept in Biology and of Advanced Imaging in Biology and Medicine: Technology, Software Environments, Applications. Brian K. Hall is University Research Professor Emeritus at Dalhousie University. His latest book is Evolution: Principles and Processes.
Epigenetics: Linking Genotype and Phenotype in Development and Evolution 1. Introduction: Emergent Properties and the Phenotype Hallgrimsson and Hall Historical and Philosophical Foundations 2. Historical Foundations Brian K. Hall 3. Heuristic Reductionism and the Relative Significance of Inheritance James Grisemer Approaches to Epigenetics 4. Genomic imprinting Vett Lloyd 5. Methylation Mapping in Humans Christoph Grunau, Montpellier 6. Asexuality and Epigenetic Variation Root Gorelick, Manfred Laubichler and Rachel Massicotte 7. Preformation and the Humpty Dumpty Problem Ellie Larsen 8. A Principle of Developmental Inertia Allesandro Minelli Epigenetics of Vertebrate Organ Development 9. Nervous System Development Carol Schuurmans 10. Morphogenesis of pigment patterns Lennart Olsson 11. Interactions of the Cardiac Neural Crest Margaret Kirby 12. Bone and Cartilage Development Tamara Franz-Odendaal 13. Muscle-Bone Interactions and the Development of Skeletal Phenotype Sue Herring 14. Apical Ectoderm in the Developing Vertebrate Limb Cooper, L.N, Armfield, B.A., J.G.M. Thewissen 15. Role of Skeletal Muscle in the Shaping of Organs, Tissues and Cell Fate Choices Boris Kablar Epigenetics in Evolution and Disease 16. Integration, Complexity and Evolvability of the Head Dan Lieberman 17. Epigenetic interactions: The developmental route to functional integration Miriam Leah Zelditcha and Donald L. Swiderski 18. Epigenetic Contributions to Adaptive Radiation Susan Foster 19. Learning, Developmental Plasticity, and the Rate of Morphological Evolution Rich Palmer and Chris Neufeld 20. Epigenetics: Adaptation or Contingency Thomas Hansen 21. Dysmorphology Joan Richtsmeier 22. Human Disease Peter Gluckman 23. Epigenetics: The Context of Development Hallgrimsson and Hall