Epilepsy is a complicated neurological condition with variable manifestations, numerous etiologies, and a diverse range of treatments. It is a chronic disease that, in many cases, can be controlled. However, treatment requires accurate clinical evaluation to allow intelligent treatment choices. Epilepsy has been designed to help clinicians develop these evaluation skills. Expert neurologists have distilled the evidence and combined their experience.
John W. Miller, MD, PhD, University of Washington, Seattle, WA, USA Howard P. Goodkin, MD, PhD, University of Virginia, Charlottesville, VA, USA
Contributor List ix Series Foreword xiii Preface xv Part I: Epilepsy Basics 1 Recognizing Seizures and Epilepsy: Insights from Pathophysiology 3 Carl E. Stafstrom 2 Classifying Epileptic Seizures and the Epilepsies 10 Valeria M. Muro and Mary B. Connolly 3 What Causes Epilepsy? 15 Anna Rosati and Renzo Guerrini 4 Epidemiology of Seizures and Epilepsy 28 Aidan Neligan and Josemir W. Sander Part II: Working up Seizures and Epilepsy 5 Diagnosing and Localizing Seizures at the Bedside and in Clinic 35 Joseph I. Sirven 6 Psychogenic Nonepileptic Episodes 42 Vaishali S. Phatak 7 What Can the EEG Tell Us? 45 Mark Quigg 8 What Can Neuroimaging Tell Us? 54 Edward J. Novotny 9 Workup of New-Onset Seizures 61 Jennifer Langer 10 Evaluation of the Patient with Medically Refractory Epilepsy 67 Gregory L. Holmes Part III: Using Antiepileptic Medications 11 Choosing, Initiating, Adjusting, and Changing Antiepileptic Medications 77 John W. Miller 12 Antiepileptic Drug Adverse Effects: What to Watch Out For 84 Jacquelyn L. Bainbridge and Caleb Y. Oh 13 Antiepileptic Drug Interactions 91 Philip N. Patsalos 14 Recognizing Intractability to Antiepileptic Medication 102 Bassel W. Abou-Khalil 15 Optimizing Antiepileptic Drug Therapy in Refractory Epilepsy 107 Nicholas P. Poolos 16 Rescue Medications for Home Treatment of Acute Seizures 112 Peter Wolf and Ruta Mameni kiene 17 When and How to Stop Antiepileptic Drugs 118 John D. Hixson 18 Using Parenteral Antiepileptic Medications 122 Jane G. Boggs 19 Pharmacopeia 126 Gail D. Anderson Part IV: Special Topics in Pediatric Epilepsy 20 Seizures in the Neonate 141 Adam L. Hartman and Frances J. Northington 21 Benign and Malignant Childhood Epilepsies 147 Katherine C. Nickels and Elaine C. Wirrell 22 Epilepsy: When to Perform a Genetic Analysis 159 Heather E. Olson and Annapurna Poduri 23 Metabolic Disorders Not to Miss 167 Phillip L. Pearl and Yuezhou Joe Yu Part V: Special Topics in Adult Epilepsy 24 Juvenile Myoclonic Epilepsy and Other Primary Generalized Epilepsies 177 Shahin Hakimian 25 Epilepsy in Women of Childbearing Age 184 Autumn Klein 26 Epilepsy After Sixty 189 Edward Faught Part VI: What can be done when medication doesn t work? 27 When Should Epilepsy Neurosurgery Be Considered, and What Can It Accomplish? 199 Paul A. Garcia 28 When Should Vagus Nerve Stimulation Be Considered, and What Can It Accomplish? 205 Pearce J. Korb and Sandra L. Helmers 29 Ketogenic Diet and Alternative Therapies 210 Dana Ekstein and Steven C. Schachter Part VII: How are acute seizures and status epilepticus evaluated and treated in the emergency department and the hospital? 30 acute Symptomatic Seizures in Children and Adults: Evaluation and Treatment 217 J. Stephen Huff and Jessica L. Carpenter 31 Evaluating and Treating Status Epilepticus 222 Jeffrey Bolton and Howard P. Goodkin 32 Recognizing, Assessing, and Treating Seizures and Status Epilepticus in the ICU 227 Nicolas Gaspard and Lawrence J. Hirsch Part VIII: The morbidity and mortality of epilepsy 33 mortality in Epilepsy 243 Elizabeth J. Donner 34 Accidents in Epilepsy 248 Allan Krumholz and Ana M. Sanchez 35 Medical Comorbidity in Epilepsy 253 Kimberly L. Pargeon and Sheryl R. Haut 36 Cognitive Effects of Chronic Epilepsy 260 Daniel L. Drane 37 Recognizing and Treating Psychiatric Comorbidity in Epilepsy 268 Jay Salpekar Index 275 Color plate section between pages 80 and 81