Analysis of the equine genome began just over a decade ago, culminating in the recent complete sequencing of the horse genome. The availability of the equine whole genome sequence represents the successful completion of an important era of equine genome analysis, and the beginning of a new era where the sequence information will catalyze the development of new tools and resources that will permit study of a range of traits that are economically important and are significant to equine health and welfare. Equine Genomics provides a timely comprehensive overview of equine genomic research. Chapters detail key accomplishments and the current state of research, as well as looking forward to possible applications of genomic technologies to horse breeding, health, and welfare. Equine Genomics delivers a global overview of the topic and is seamlessly edited by a leading equine genomics researcher. Equine Genomics is an indispensible source of information for anyone with an interest in this increasingly important field of study, including equine genomic researchers, clinicians, animal science professionals and equine field veterinarians.
Bhanu Chowdhary is a Professor of Veterinary Anatomy and Public Health at Texas A & M University.
Contributors ix Preface xi Chapter 1 Defining the equine genome: The nuclear genome and the mitochondrial genome 1 Bhanu P. Chowdhary Chapter 2 Genetic linkage maps 11 June Swinburne and Gabriella Lindgren Chapter 3 Physical and comparative maps 49 Terje Raudsepp and Bhanu P. Chowdhary Chapter 4 The Y-chromosome 73 Terje Raudsepp, Nandina Paria, and Bhanu P. Chowdhary Chapter 5 Unexpected structural features of the equine major histocompatibility complex 93 Loren C. Skow and Candice L. Brinkmeyer-Langford Chapter 6 Assembly and analysis of the equine genome sequence 103 Claire M. Wade Chapter 7 Genomic tools and resources: Development and applications of an equine SNP genotyping array 113 Molly McCue and Jim Mickelson Chapter 8 Functional genomics 125 Stephen J. Coleman, Michael J. Mienaltowski, and James N. MacLeod Chapter 9 Coat color genomics 143 Samantha A. Brooks and Rebecca R. Bellone Chapter 10 Genomics of skin disorders 155 Amy E. Young, Stephen D. White, and Danika L. Bannasvch Chapter 11 Genomics of muscle disorders 171 James R. Mickelson, Stephanie J. Valberg, Carrie J. Finno, and Molly E. McCue Chapter 12 Genomics of skeletal disorders 187 Ottmar Distl Chapter 13 Genomics of reproduction and fertility 199 Terje Raudsepp, Pranab J. Das and Bhanu P. Chowdhary Chapter 14 Genetics of equine neurologic disease 217 Carrie J. Finno and Monica Aleman Chapter 15 Molecular genetic testing and karyotyping in the horse 241 M. C. T. Penedo and Terje Raudsepp Chapter 16 Genomics of laminitis 255 Jim K. Belknap Chapter 17 Genomics of performance 265 Emmeline W. Hill, Lisa M. Katz, and David E. MacHugh Chapter 18 Genomics of the circadian clock 285 Barbara A. Murphy Chapter 19 Mitochondrial genome: Clues about the evolution of extant equids and genomic diversity of horse breeds 311 Cynthia C. Steiner, Kateryna D. Makova, and Oliver A. Ryder Index 323 Color plate is located between pages 216 and 217.