A highly innovative textbook offering an integrated approach to biochemistry as applications of chemistry in health and medicine are used to illustrate the key concepts. Organic and biochemistry concepts are included in every chapter, so that students can engage in topics directly related to their study. This text provides students with everything they need to learn the fundamentals of chemistry in the context of their future careers.
Connections between chemical concepts and healthcare are made throughout each chapter by beginning with an opening relevant story, moving on to covering the chemical concept and ending each chapter.
Denise Guinn received her BA in chemistry from the University of California at San Diego and her Ph.D. in organic chemistry from the University of Texas at Austin. She was a National Institutes of Health postdoctoral fellow at Harvard University before joining Abbott Laboratories as a Research Scientist in the Pharmaceutical Products Discovery Research Group. Her area of research is synthetic organic chemistry; she has published in the Journal of Organic Chemistry, the Journal of the American Chemical Society, and the Journal of Medicinal Chemistry.
1. Measuring Matter and Energy 1.1 Matter and Energy 1.2 Metric and English Units 1.3 Significant Figures in Measurements 1.4 Dimensional Analysis and Unit Conversion.- 2. Atomic Structure and Nuclear Radiation 2.1 Elements and the Structure of the Atom 2.2 The Periodic Table of Elements 2.3 Electrons 2.4 Ions 2.5 Radioisotopes and Nuclear Radiation.- 3. Compounds and Molecules 3.1 Ionic Compounds 3.2 Covalent Compounds 3.3 Shapes of Covalent Molecules 3.4 Polar Bonds and Polar Molecules 3.5 Intermolecular Forces of Attraction.- 4. Chemical Reactions and Chemical Quantities 4.1 The Mole: Counting and Weighing Matter 4.2 Writing and Balancing a Chemical Equation 4.3 Energy and Chemical Reactions 4.4 Reaction Kinetics 4.5 Chemical Equilibrium.- 5. Changes of State and the Gas Laws 5.1 Changes of State 5.2 The Gas Laws 5.3 Gas Mixtures and Partial Pressure.- 6. Hydrocarbons 6.1 Introduction to Hydrocarbons 6.2 Structure of Alkanes 6.3 Writing Alkane Structures 6.4 Unsaturated Hydrocarbons: Alkenes and Alkynes 6.5 Naming Hydrocarbons 6.6 Aromatic Hydrocarbons.- 7. Organic Chemistry and Biomolecules 7.1 Alcohols and Ethers 7.2 Amines 7.3 Carbonyl Containing Functional Groups 7.4 Stereoisomers 7.5 Phosphate Ester Functional Groups.- 8. Mixtures, Solution Concentrations, and Diffusion 8.1 Mixtures and Solutions.8.2 Solution Concentrations.8.3 Colloidal Dispersions and Suspensions.8.4 Diffusion of Solutes and Solvent through Membranes.- 9. Acids and Bases 9.1 Acids and Bases 9.2 pH 9.3 Buffers.- 10. The Reactions of Organic Functional Groups in Biochemistry.10.1 Oxidation-Reduction Reactions 10.2 Group Transfer Reactions: Esterification and Amidation Reactions 10.3 Hydrolysis Reactions 10.4 Addition-Elimination Reactions involving Water: Hydration and Dehydration.- 11. Carbohydrates: Structure and Function 11.1 An Overview of Carbohydrates and their Function.11.2 The Structure of the Common Monosaccharides.11.3 The Structure of Complex Carbohydrates.11.4 The Role of Oligosaccharides as Cell Markers.- 12. Lipids: Structure and Function.12.1 Fatty Acids: A Component of Many Lipids.12.2 Triglycerides: Energy Storage Lipids 12.3 Phospholipid and Glycolipid Membrane Lipids 12.4 Cholesterol, Steroids and Lipoproteins.- 13. Proteins: Structure and Function 13.1 Amino Acids 13.2 Peptides 13.3 Protein Architecture 13.4 Enzymes.- 14. Nucleotides and Nucleic Acids 14.1 The Chemical Structure of Nucleotide and Polynucleotides 14.2 DNA Structure and Replication 14.3 The Role of DNA and RNA in Protein Synthesis.- 15. Metabolism and Bioenergetics 15.1 Overview of Energy and Metabolism 15.2 Carbohydrate Catabolism 15.3 Fatty Acid Catabolism 15.4 The Citric Acid Cycle 15.5 Oxidative Phosphorylation.